Pub. Date : 2015 Dec
PMID : 26438057
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Core domain mutant Y220C of p53 protein has a key role in copper homeostasis in case of free fatty acids overload. | Copper | tumor protein p53 | Homo sapiens |
| 2 | Here we provide evidence on the role of p53 in the modulation of copper homeostasis, in an experimental model of NAFLD. | Copper | tumor protein p53 | Homo sapiens |
| 3 | Interestingly, p53 activation correlated with the intracellular copper level maintenance. | Copper | tumor protein p53 | Homo sapiens |
| 4 | We demonstrated that, in hepatoma cell lines, core domain mutant Y220C of p53 affects the modulation of SCO2 and Copper transporter 1 (CTR1), influencing, in this way, intracellular copper homeostasis in presence of FFAs accumulation, and that the 220 residue of the protein is crucial for such control. | Copper | tumor protein p53 | Homo sapiens |
| 5 | The role of p53 we highlighted may have deep implications in clinical conditions where copper homeostasis is deregulated. | Copper | tumor protein p53 | Homo sapiens |