Pub. Date : 2004 Mar 15
PMID : 15001399
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc. | Copper | tumor protein p53 | Homo sapiens |
| 2 | Exposure to copper and zinc increased Akt phosphorylation with its nuclear localization only in MDA-MB-231 cells with no estrogen receptor and mutated p53. | Copper | tumor protein p53 | Homo sapiens |
| 3 | In contrast, in MCF-7 cells with wild type p53 and estrogen receptor, there was no change in Akt activation, while suppression of p53 activity by pifithrin-alpha increased phosphorylation of Akt after the treatment with copper. | Copper | tumor protein p53 | Homo sapiens |
| 4 | These results demonstrate that copper-induced apoptosis in MCF-7 cells is p53 dependent, whereas the metal resistance in MDA-MB-231 cells may be due to activation of Akt in the absence of a functional p53. | Copper | tumor protein p53 | Homo sapiens |