2-Methoxyestradiol

tumor protein p53 ; Homo sapiens







29 Article(s)
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1 34085157 Proline oxidase silencing inhibits p53-dependent apoptosis in MCF-7 breast cancer cells. 2021 Dec 1
2 29193609 Endogenous hormone 2-methoxyestradiol suppresses venous hypertension-induced angiogenesis through up- and down-regulating p53 and id-1. 2018 Feb 1
3 25948191 [2-methoxyestradiol induced apoptosis and expression of p53 gene in human acute T lymphoblastic leukemia cells]. 2015 Apr 1
4 25179905 Tumor suppressor protein p53 promotes 2-methoxyestradiol-induced activation of Bak and Bax, leading to mitochondria-dependent apoptosis in human colon cancer HCT116 cells. 2014 Dec 28 3
5 21344307 2ME and 2OHE2 exhibit growth inhibitory effects and cell cycle arrest at G2/M in RL95-2 human endometrial cancer cells through activation of p53 and Chk1. 2011 Jun 1
6 22077725 Effects of estrogen metabolite 2-methoxyestradiol on tumor suppressor protein p53 and proliferation of breast cancer cells. 2011 Dec 1
7 19949306 Evidence for the interplay between JNK and p53-DRAM signalling pathways in the regulation of autophagy. 2010 Jan 2
8 19706754 c-Jun NH2-terminal kinase activation is essential for DRAM-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-treated Ewing sarcoma cells. 2009 Sep 1 3
9 19715480 p53 gene expression and 2-methoxyestradiol treatment differentially induce nuclear factor kappa B activation in human lung cancer cells with different p53 phenotypes. 2009 Dec 12
10 18384113 2-methoxyestradiol-induced cell death in osteosarcoma cells is preceded by cell cycle arrest. 2008 Aug 1 1
11 17472413 INGN 201: Ad-p53, Ad5CMV-p53, adenoviral p53, p53 gene therapy--introgen, RPR/INGN 201. 2007 1
12 16356831 2-Methoxyestradiol and paclitaxel have similar effects on the cell cycle and induction of apoptosis in prostate cancer cells. 2006 Jan 8 1
13 16824077 A very low toxic agent induces apoptosis and reduces growth of human hepatocellular carcinoma cells. 2006 Jul 1
14 15312684 2-Methoxyestradiol inhibits proliferation of normal and neoplastic glial cells, and induces cell death, in vitro. 2004 Sep 15 1
15 15525476 2-Methoxyestradiol induces cell cycle arrest and apoptosis of nasopharyngeal carcinoma cells. 2004 Nov 1
16 15551755 2-methoxyestradiol enhances p53 protein transduction therapy-associated inhibition of the proliferation of oral cancer cells through the suppression of NFkappaB activity. 2004 Aug 6
17 12690294 Cell cycle block and apoptosis induction in a human melanoma cell line following treatment with 2-methoxyoestradiol: therapeutic implications? 2003 Apr 1
18 12730670 2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production. 2003 May 1 1
19 12807754 Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. 2003 Jun 3
20 14599859 2-methoxyestradiol strongly inhibits human uterine sarcomatous cell growth. 2003 Nov 2
21 12359354 2-Methoxyestradiol induces p53-associated apoptosis of colorectal cancer cells. 2002 Dec 10 2
22 11479920 2-methoxyestradiol blocks cell-cycle progression at G(2)/M phase and inhibits growth of human prostate cancer cells. 2001 Jul 3
23 11072172 Oral administration of an estrogen metabolite-induced potentiation of radiation antitumor effects in presence of wild-type p53 in non-small-cell lung cancer. 2000 Nov 1 1
24 9674709 Superinduction of wild-type p53 protein after 2-methoxyestradiol treatment of Ad5p53-transduced cells induces tumor cell apoptosis. 1998 Jul 16 7
25 9809972 An agent that increases tumor suppressor transgene product coupled with systemic transgene delivery inhibits growth of metastatic lung cancer in vivo. 1998 Nov 1 2
26 14646475 Two-dimensional gel analysis of apoptosis-specific p53 isoforms induced by 2-methoxyestradiol in human lung cancer cells. 1998 Dec 8
27 9018125 Induction of apoptosis in human lung cancer cells after wild-type p53 activation by methoxyestradiol. 1997 Jan 23 7
28 9408079 The mammalian metabolite, 2-methoxyestradiol, affects P53 levels and apoptosis induction in transformed cells but not in normal cells. 1997 Jul 1
29 8982610 Analysis of phosphorylated isoforms of the p53 tumor suppressor protein in human lung carcinoma cells undergoing apoptosis. 1996 Nov 1