Pub. Date : 2004 Aug
PMID : 15551755
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | 2-methoxyestradiol enhances p53 protein transduction therapy-associated inhibition of the proliferation of oral cancer cells through the suppression of NFkappaB activity. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |
2 | However, the intracellular half-life of the delivered protein was less than 36 h. Previous studies also showed that 2-methoxyestradiol (2-ME), an endogenous non-toxic estrogenic metabolite, induces the stabilization of the wild-type p53 protein in human cancer cells posttranscriptionally. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |
3 | However, the intracellular half-life of the delivered protein was less than 36 h. Previous studies also showed that 2-methoxyestradiol (2-ME), an endogenous non-toxic estrogenic metabolite, induces the stabilization of the wild-type p53 protein in human cancer cells posttranscriptionally. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |
4 | In the present study, we examined whether 2-ME induced the stabilization of 11R-p53 and had an inhibitory effect on the proliferation of oral cancer cells. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |
5 | The application of 2-ME significantly enhanced the inhibitory effect of 11R-p53 on the proliferation of oral cancer cells. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |
6 | These results suggest that 2-ME synergistically enhances the 11R-p53-induced inhibition of the proliferation of oral cancer cells through the suppression of NFkB transcription. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |