Title : 2-methoxyestradiol enhances p53 protein transduction therapy-associated inhibition of the proliferation of oral cancer cells through the suppression of NFkappaB activity.

Pub. Date : 2004 Aug

PMID : 15551755






6 Functional Relationships(s)
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1 2-methoxyestradiol enhances p53 protein transduction therapy-associated inhibition of the proliferation of oral cancer cells through the suppression of NFkappaB activity. 2-Methoxyestradiol tumor protein p53 Homo sapiens
2 However, the intracellular half-life of the delivered protein was less than 36 h. Previous studies also showed that 2-methoxyestradiol (2-ME), an endogenous non-toxic estrogenic metabolite, induces the stabilization of the wild-type p53 protein in human cancer cells posttranscriptionally. 2-Methoxyestradiol tumor protein p53 Homo sapiens
3 However, the intracellular half-life of the delivered protein was less than 36 h. Previous studies also showed that 2-methoxyestradiol (2-ME), an endogenous non-toxic estrogenic metabolite, induces the stabilization of the wild-type p53 protein in human cancer cells posttranscriptionally. 2-Methoxyestradiol tumor protein p53 Homo sapiens
4 In the present study, we examined whether 2-ME induced the stabilization of 11R-p53 and had an inhibitory effect on the proliferation of oral cancer cells. 2-Methoxyestradiol tumor protein p53 Homo sapiens
5 The application of 2-ME significantly enhanced the inhibitory effect of 11R-p53 on the proliferation of oral cancer cells. 2-Methoxyestradiol tumor protein p53 Homo sapiens
6 These results suggest that 2-ME synergistically enhances the 11R-p53-induced inhibition of the proliferation of oral cancer cells through the suppression of NFkB transcription. 2-Methoxyestradiol tumor protein p53 Homo sapiens