Pub. Date : 2003 Jun
PMID : 12807754
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |
| 2 | It was found that 2-ME mediates apoptosis through p53 induction. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |
| 3 | The results suggest that not only p53 induction through p38/JNK-dependent NFkappaB/AP-1 activation but also JNK-dependent Bcl-2 phosphorylation are required for 2-ME-induced apoptosis; moreover, inhibition of these pathways may be involved in androgen-mediated resistance to apoptosis. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |