Title : Inhibition of MDM2 Re-Sensitizes Rapamycin Resistant Renal Cancer Cells via the Activation of p53.

Pub. Date : 2016

PMID : 27825169






2 Functional Relationships(s)
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1 Importantly, the rapamycin resistant cells demonstrated attenuated accumulation of p53 in the nucleus in response to rapamycin treatment. Sirolimus tumor protein p53 Homo sapiens
2 Moreover, the inhibition of MDM2 by siMDM2 sensitizes A498 cells to rapamycin through the activation of p53. Sirolimus tumor protein p53 Homo sapiens