| 1 |
34886743 | Fludarabine nucleoside induces major changes in the p53 interactome in human B-lymphoid cancer cell lines. | 2022 |
3 |
| 2 |
35211418 | Impact of Low-Burden TP53 Mutations in the Management of CLL. | 2022 |
1 |
| 3 |
31289209 | HIF-1α is over-expressed in leukemic cells from TP53-disrupted patients and is a promising therapeutic target in chronic lymphocytic leukemia. | 2020 Apr |
2 |
| 4 |
32253666 | Evolution in the management of chronic lymphocytic leukemia in Japan: should MRD negativity be the goal? | 2020 May |
1 |
| 5 |
31226417 | Entinostat combined with Fludarabine synergistically enhances the induction of apoptosis in TP53 mutated CLL cells via the HDAC1/HO-1 pathway. | 2019 Sep 1 |
4 |
| 6 |
24144307 | The histone deacetylase inhibitor SAHA sensitizes acute myeloid leukemia cells to a combination of nucleoside analogs and the DNA-alkylating agent busulfan. | 2014 Jul |
1 |
| 7 |
25119920 | [Detection of p53 gene deletion in Xinjiang patients with chronic lymphocytic leukemia by fluorescence in situ hybridization and its clinical significance]. | 2014 Aug |
2 |
| 8 |
23821658 | NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG. | 2013 Aug 15 |
2 |
| 9 |
22149137 | The Hsp90 inhibitor SNX-7081 synergizes with and restores sensitivity to fludarabine in chronic lymphocytic leukemia cells with lesions in the TP53 pathway: a potential treatment strategy for fludarabine refractory disease. | 2012 Jul |
4 |
| 10 |
22308293 | Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia. | 2012 Mar 22 |
1 |
| 11 |
22641291 | Fludarabine nucleoside induces accumulations of p53, p63 and p73 in the nuclei of human B-lymphoid cell lines, with cytosolic and mitochondrial increases in p53. | 2012 Jun |
2 |
| 12 |
22937789 | S-MDM4 mRNA overexpression indicates a poor prognosis and marks a potential therapeutic target in chronic lymphocytic leukemia. | 2012 Dec |
1 |
| 13 |
22962562 | Heterogeneity of p53-pathway Protein Expression in Chemosensitive Chronic Lymphocytic Leukemia: A Pilot Study. | 2012 |
1 |
| 14 |
23052131 | Expression level of DEK in chronic lymphocytic leukemia is regulated by fludarabine and Nutlin-3 depending on p53 status. | 2012 Dec |
3 |
| 15 |
21521181 | A pilot monocentric analysis of efficacy and safety of Fludarabine-Campath combination (Flucam) as first line treatment in elderly patients with chronic lymphocytic leukaemia and Tp53 disfunction. | 2011 Jul |
1 |
| 16 |
22039264 | Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness. | 2011 Dec 22 |
1 |
| 17 |
23556086 | Treatment options for high-risk chronic lymphocytic leukaemia. | 2011 Jun |
3 |
| 18 |
20504344 | MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia. | 2010 May 26 |
3 |
| 19 |
19018867 | Presence of heterozygous ATM deletion may not be critical in the primary response of chronic lymphocytic leukemia cells to fludarabine. | 2009 Feb |
2 |
| 20 |
19643983 | Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial. | 2009 Sep 24 |
1 |
| 21 |
19778838 | Flavopiridol in chronic lymphocytic leukemia: a concise review. | 2009 |
1 |
| 22 |
17728781 | Multiple forms of nuclear p53 formed in human Raji and MEC1 cells treated with fludarabine. | 2008 Mar |
1 |
| 23 |
18092340 | Differential effects of chemotherapeutic drugs versus the MDM-2 antagonist nutlin-3 on cell cycle progression and induction of apoptosis in SKW6.4 lymphoblastoid B-cells. | 2008 May 15 |
2 |
| 24 |
18945750 | Identification of TIGAR in the equilibrative nucleoside transporter 2-mediated response to fludarabine in chronic lymphocytic leukemia cells. | 2008 Dec |
1 |
| 25 |
19062342 | Dasatinib sensitizes primary chronic lymphocytic leukaemia lymphocytes to chlorambucil and fludarabine in vitro. | 2008 Dec |
1 |
| 26 |
17226861 | Drug resistance in B-cell chronic lymphocytic leukemia: predictable by in vitro evaluation with a multiparameter flow cytometric cytotoxicity assay. | 2007 May |
1 |
| 27 |
17325891 | 17p Deletion is associated with resistance of B-cell chronic lymphocytic leukemia cells to in vitro fludarabine-induced apoptosis. | 2007 Feb |
1 |
| 28 |
16501812 | Fludarabine induces apoptosis in chronic lymphocytic leukemia--the role of P53, Bcl-2, Bax, Mcl-1, and Bag-1 proteins. | 2006 Mar |
1 |
| 29 |
16543464 | Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia. | 2006 Aug 1 |
3 |
| 30 |
16741250 | CD154 induces p73 to overcome the resistance to apoptosis of chronic lymphocytic leukemia cells lacking functional p53. | 2006 Nov 15 |
1 |
| 31 |
15138159 | Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response. | 2004 Sep 1 |
8 |
| 32 |
15217838 | Differential roles of STAT1alpha and STAT1beta in fludarabine-induced cell cycle arrest and apoptosis in human B cells. | 2004 Oct 15 |
2 |
| 33 |
12719725 | Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy. | 2003 Apr |
1 |
| 34 |
12912974 | Activation of a p53-mediated apoptotic pathway in quiescent lymphocytes after the inhibition of DNA repair by fludarabine. | 2003 Aug 1 |
2 |
| 35 |
14623330 | Involvement of p53 in alpha4beta1 integrin-mediated resistance of B-CLL cells to fludarabine. | 2003 Nov 21 |
2 |
| 36 |
12085225 | Resistance to fludarabine-induced apoptosis in Epstein-Barr virus infected B cells. | 2002 Jul 4 |
1 |
| 37 |
12176904 | Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia. | 2002 Sep 1 |
1 |
| 38 |
11526536 | Mechanisms of cell death induced by suicide genes encoding purine nucleoside phosphorylase and thymidine kinase in human hepatocellular carcinoma cells in vitro. | 2001 Sep |
3 |
| 39 |
9703875 | Increased p21/WAF-1 and p53 protein levels following sequential three drug combination regimen of fludarabine, cytarabine and docetaxel induces apoptosis in human leukemia cells. | 1998 Jul-Aug |
1 |
| 40 |
9389352 | P53, MDM-2, BAX and BCL-2 and drug resistance in chronic lymphocytic leukemia. | 1997 Aug |
2 |
| 41 |
9499672 | Prognostic value of biological variables in B-cell chronic lymphocytic leukemia. Can we improve upon clinical parameters? | 1997 Nov-Dec |
1 |