Pub. Date : 2019 Sep 1
PMID : 31226417
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Entinostat combined with Fludarabine synergistically enhances the induction of apoptosis in TP53 mutated CLL cells via the HDAC1/HO-1 pathway. | fludarabine | tumor protein p53 | Homo sapiens |
| 2 | Worse still, CLL patients with TP53 mutation are associated with poor efficacy to current chemotherapeutic, such as Fludarabine. | fludarabine | tumor protein p53 | Homo sapiens |
| 3 | Subsequently, we demonstrated Entinostat (HDAC1 inhibitor) combination with Fludarabine significantly induced apoptosis in TP53 mutations CLL cells. | fludarabine | tumor protein p53 | Homo sapiens |
| 4 | Finally, combining vitro and vivo experiments, we presented the first demonstration that Entinostat combination with Fludarabine had a synergistic effect on the induction of apoptosis in TP53 mutations CLL cells. | fludarabine | tumor protein p53 | Homo sapiens |