Threonine

tumor protein p53 ; Homo sapiens







65 Article(s)
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1 35149588 CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade. 2022 Apr 1 1
2 32705438 Specific Smad2/3 Linker Phosphorylation Indicates Esophageal Non-neoplastic and Neoplastic Stem-Like Cells and Neoplastic Development. 2021 Jun 1
3 33256128 Exploiting GRK2 Inhibition as a Therapeutic Option in Experimental Cancer Treatment: Role of p53-Induced Mitochondrial Apoptosis. 2020 Nov 26 2
4 30683654 PAK4 Phosphorylates Fumarase and Blocks TGFβ-Induced Cell Growth Arrest in Lung Cancer Cells. 2019 Apr 1 1
5 27902328 Hepatitis C virus core activates proteasomal activator 28γ expression via upregulation of p53 levels to control virus propagation. 2017 Jan 1
6 28539160 Phosphorylation of p53 at threonine 155 is required for Jab1-mediated nuclear export of p53. 2017 Jul 3
7 28714848 Hepatitis B virus X protein activates E3 ubiquitin ligase Siah-1 to control virus propagation via a negative feedback loop. 2017 Jul 1
8 27125496 Novel method for the high-throughput production of phosphorylation site-specific monoclonal antibodies. 2016 Apr 29 1
9 27147566 JNK2 downregulation promotes tumorigenesis and chemoresistance by decreasing p53 stability in bladder cancer. 2016 Jun 7 2
10 24998852 Physical and functional interaction of the TPL2 kinase with nucleophosmin. 2015 May 7 1
11 25651062 An acetyl-methyl switch drives a conformational change in p53. 2015 Feb 3 1
12 26029824 Real-time and simultaneous monitoring of the phosphorylation and enhanced interaction of p53 and XPC acidic domains with the TFIIH p62 subunit. 2015 Jun 1 1
13 26333122 Subcellular Localization of Proteins Responding to Mitoxantrone-Induced DNA Damage in Leukaemic Cells. 2015 1
14 24492002 VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage. 2014 Mar 3 1
15 24833091 Novel p53 codon 240 Ser > Thr coding region mutation in the patients of oral squamous cell carcinoma (OSCC). 2014 Aug 1
16 22112863 The HDAC inhibitor depsipeptide transactivates the p53/p21 pathway by inducing DNA damage. 2012 Feb 1 1
17 22288499 p53 Ser15 phosphorylation disrupts the p53-RPA70 complex and induces RPA70-mediated DNA repair in hypoxia. 2012 May 1 1
18 22315229 HEAT repeat 1 motif is required for B56γ-containing protein phosphatase 2A (B56γ-PP2A) holoenzyme assembly and tumor-suppressive function. 2012 Mar 30 3
19 22505655 p53 N-terminal phosphorylation: a defining layer of complex regulation. 2012 Aug 1
20 23350039 N-acetylglucosamine (GlcNAc) functions in cell signaling. 2012 Jan 1 1
21 20959462 Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. 2011 Jan 21 1
22 21465572 Redox modulation of p53: mechanisms and functional significance. 2011 Apr 1
23 22312557 The Role of Wild-Type p53 in Cisplatin-Induced Chk2 Phosphorylation and the Inhibition of Platinum Resistance with a Chk2 Inhibitor. 2011 1
24 19965871 ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. 2010 Feb 12 1
25 20167603 DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. 2010 Apr 23 1
26 19166313 Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation. 2009 Feb 17 3
27 19217391 Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation. 2009 Feb 13 2
28 19651615 Control of p53 multimerization by Ubc13 is JNK-regulated. 2009 Aug 4 3
29 19819244 Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53. 2009 Dec 18 1
30 19890497 Pin1 as an anticancer drug target. 2009 Sep 1
31 18443131 Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis. 2008 Jun 2
32 18952844 Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage. 2008 Nov 4 6
33 17957142 Modulation of the p53-MDM2 interaction by phosphorylation of Thr18: a computational study. 2007 Nov 1 1
34 16964247 Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability. 2006 Oct 3
35 17010455 Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B. 2006 Nov 4
36 15807522 Substrate specificity of the human protein phosphatase 2Cdelta, Wip1. 2005 Apr 12 2
37 16123044 Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1. 2005 Oct 21 1
38 14729628 p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF. 2004 Jan 1 1
39 15053879 Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression. 2004 Mar 26 3
40 15116093 Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death. 2004 Apr 29 1
41 15175154 The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. 2004 Jun 4 1
42 15274301 Selenium compounds regulate p53 by common and distinctive mechanisms. 2004 May-Jun 1
43 15355354 Structured DNA promotes phosphorylation of p53 by DNA-dependent protein kinase at serine 9 and threonine 18. 2004 Sep 1
44 12531896 The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. 2003 Apr 4 1
45 12897801 Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain. 2003 Aug 3
46 14660794 Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin. 2003 Dec 23 1
47 11707453 Regulation of the accumulation and function of p53 by phosphorylation of two residues within the domain that binds to Mdm2. 2002 Jan 18 2
48 11875057 ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. 2002 Apr 12 2
49 11890931 SN2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression. 2002 Mar 20 1
50 12388558 Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage. 2002 Dec 13 2