Title : CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade.

Pub. Date : 2022 Apr 1

PMID : 35149588






1 Functional Relationships(s)
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1 We found that CDK4/6 bind and phosphorylate the p53 family member p73 at threonine 86, which sequesters p73 in the cytoplasm. Threonine tumor protein p53 Homo sapiens