Disulfides

insulin ; Homo sapiens







246 Article(s)
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Pub. Year
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1 35066065 A novel method for the chaperone aided and efficient production of human proinsulin in the prokaryotic system. 2022 Feb 20 1
2 35104142 Molecular Engineering of Efficacious Mono-Valent Ultra-Long Acting Two-Chain Insulin-Fc Conjugates. 2022 Feb 10 1
3 35299958 Peptide Model of the Mutant Proinsulin Syndrome. II. Nascent Structure and Biological Implications. 2022 1
4 35299972 Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation. 2022 1
5 35427577 Structural view of insulin adsorption on the multiple sizes of Cu nanoparticles; molecular dynamics simulation study. 2022 Jun 15 1
6 35460376 Circulating protein disulfide isomerase family member 4 is associated with type 2 diabetes mellitus, insulin sensitivity, and obesity. 2022 Apr 23 1
7 35617668 Virtual Quasi-2D Intermediates as Building Blocks for Plausible Structural Models of Amyloid Fibrils from Proteins with Complex Topologies: A Case Study of Insulin. 2022 Jun 7 2
8 32311837 A SERS quenching method for the sensitive determination of insulin. 2021 May 3
9 33231477 Augmented Two-Dimensional Correlation Spectroscopy for the Joint Analysis of Correlated Changes in Spectroscopic and Disparate Sources. 2021 May 3
10 33518643 [Studies on Functional Molecules Based on Peptide Chemistry]. 2021 3
11 33689304 The Chemical Synthesis of Insulin: An Enduring Challenge. 2021 Apr 28 1
12 33797881 Chemical Synthesis of Phosphorylated Insulin-like Growth Factor Binding Protein 2. 2021 Apr 14 1
13 34174481 In celebration of a century with insulin - Update of insulin gene mutations in diabetes. 2021 Oct 2
14 34245311 Distinct states of proinsulin misfolding in MIDY. 2021 Aug 5
15 34271044 A tale of two tails: Self-assembling properties of A- and B-chain parts of insulin's highly amyloidogenic H-fragment. 2021 Sep 1 1
16 34564928 Thiol/disulfide homeostasis and its relationship with insulin resistance in patients with rosacea. 2021 Sep 26 1
17 34797669 Engineering of a Biologically Active Insulin Dimer. 2021 Dec 9 1
18 35069438 A Novel Nonsense INS Mutation Causes Inefficient Preproinsulin Translocation Into the Endoplasmic Reticulum. 2021 1
19 32070740 Rapid self-association of highly amyloidogenic H-fragments of insulin: Experiment and molecular dynamics simulations. 2020 May 1 1
20 32110371 Novel four-disulfide insulin analog with high aggregation stability and potency. 2020 Jan 7 5
21 32196765 The ABC of Insulin: The Organic Chemistry of a Small Protein. 2020 Jul 8 1
22 32309706 Direct Ultraviolet Laser-Induced Reduction of Disulfide Bonds in Insulin and Vasopressin. 2020 Apr 14 1
23 32376199 New insights into serum/extracellular thioredoxin in regulating hepatic insulin receptor activation. 2020 Aug 1
24 32428440 Exploration of Insulin Amyloid Polymorphism Using Raman Spectroscopy and Imaging. 2020 Jun 16 1
25 32916194 Biological behaviors of mutant proinsulin contribute to the phenotypic spectrum of diabetes associated with insulin gene mutations. 2020 Dec 1 6
26 32988199 Extremely Amyloidogenic Single-Chain Analogues of Insulin's H-Fragment: Structural Adaptability of an Amyloid Stretch. 2020 Oct 20 3
27 33154160 Evolution of insulin at the edge of foldability and its medical implications. 2020 Nov 24 1
28 33159202 Production of a novel heterodimeric two-chain insulin-Fc fusion protein. 2020 Sep 14 1
29 33159537 SUMOylation of Pdia3 exacerbates proinsulin misfolding and ER stress in pancreatic beta cells. 2020 Dec 1
30 29947407 Synthesis of hydrophobic insulin-based peptides using a helping hand strategy. 2019 Feb 13 1
31 30252537 Complexation of novel thiomers and insulin to protect against in vitro enzymatic degradation - towards oral insulin delivery. 2019 Jan 1
32 30604098 Functionality of an absolutely conserved glycine residue in the chimeric relaxin family peptide R3/I5. 2019 Apr 1
33 30807169 Mobility Capillary Electrophoresis-Restrained Modeling Method for Protein Structure Analysis in Mixtures. 2019 Mar 14 1
34 30915639 A novel mutation in INS gene linked to permanent neonatal diabetes mellitus. 2019 Jun 1
35 30924212 Rapid Photolysis-Mediated Folding of Disulfide-Rich Peptides. 2019 Jun 26 1
36 30980592 Beyond amino acid sequence: disulfide bonds and the origins of the extreme amyloidogenic properties of insulin's H-fragment. 2019 Aug 4
37 31012517 Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin. 2019 Jun 26 2
38 31158417 Defective endoplasmic reticulum export causes proinsulin misfolding in pancreatic β cells. 2019 Aug 1 1
39 31184302 Proinsulin misfolding is an early event in the progression to type 2 diabetes. 2019 Jun 11 1
40 31343157 A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity. 2019 Aug 16 3
41 28988628 Challenges in the design of insulin and relaxin/insulin-like peptide mimetics. 2018 Jun 1 1
42 29064322 Interaction mechanism of insulin with ZnO nanoparticles by replica exchange molecular dynamics simulation. 2018 Nov 1
43 29377149 Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes. 2018 Apr 4
44 29596046 Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. 2018 Mar 29 2
45 29902373 Characterization of Disulfide Linkages in Proteins by 193 nm Ultraviolet Photodissociation (UVPD) Mass Spectrometry. 2018 Jul 17 1
46 30339677 Human αB-crystallin as fusion protein and molecular chaperone increases the expression and folding efficiency of recombinant insulin. 2018 1
47 30350608 Acetone/Isopropanol Photoinitiating System Enables Tunable Disulfide Reduction and Disulfide Mapping via Tandem Mass Spectrometry. 2018 Nov 6 3
48 30542587 Facile folding of insulin variants bearing a prosthetic C-peptide prepared by α-ketoacid-hydroxylamine (KAHA) ligation. 2018 Nov 28 2
49 27719550 Development of shell cross-linked nanoparticles based on boronic acid-related reactions for self-regulated insulin delivery. 2017 Jan 1
50 28319665 Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation. 2017 Apr 7 5