Title : Molecular Engineering of Efficacious Mono-Valent Ultra-Long Acting Two-Chain Insulin-Fc Conjugates.

Pub. Date : 2022 Feb 10

PMID : 35104142






1 Functional Relationships(s)
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1 Insulin-Fc conjugates were synthesized using trifunctional linkers with one amino reactive group for reaction with a lysine residue of insulin and two thiol reactive groups used for re-bridging of a disulfide bond within the Fc molecule. Disulfides insulin Homo sapiens