venetoclax

MCL1 apoptosis regulator, BCL2 family member ; Homo sapiens







25 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 34728569 Anti-apoptotic MCL1 Protein Represents Critical Survival Molecule for Most Burkitt Lymphomas and BCL2-negative Diffuse Large B-cell Lymphomas. 2022 Jan 1
2 34767916 Cotargeting of Bcl-2 and Mcl-1 shows promising antileukemic activity against AML cells including those with acquired cytarabine resistance. 2022 Jan 2
3 35443722 Artesunate improves venetoclax plus cytarabine AML cell targeting by regulating the Noxa/Bim/Mcl-1/p-Chk1 axis. 2022 Apr 20 1
4 35443750 The BCL-2 inhibitor ABT-199/venetoclax synergizes with proteasome inhibition via transactivation of the MCL-1 antagonist NOXA. 2022 Apr 20 1
5 32165486 The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia. 2021 May 1 1
6 34331013 Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. 2021 Sep 1
7 32066201 Venetoclax, bortezomib and S63845, an MCL1 inhibitor, in multiple myeloma. 2020 May 1
8 32184020 Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells. 2020 May 14 1
9 30008477 The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells. 2019 Jan 2
10 31115744 Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo. 2019 Jun 1
11 31320594 Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia. 2019 Nov 15 2
12 31515455 Improving Response to FLT3 Inhibitors-BCL2 the Rescue? 2019 Nov 15 1
13 29559471 Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells. 2018 Jun 1 2
14 29761903 The combination of a sphingosine kinase 2 inhibitor (ABC294640) and a Bcl-2 inhibitor (ABT-199) displays synergistic anti-myeloma effects in myeloma cells without a t(11;14) translocation. 2018 May 15 1
15 30021909 Tyrosine Kinase Inhibitors Increase MCL1 Degradation and in Combination with BCLXL/BCL2 Inhibitors Drive Prostate Cancer Apoptosis. 2018 Nov 1 1
16 30185627 A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia. 2018 Dec 1
17 30701031 Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells. 2018 Dec 28 1
18 28578655 Potential mechanisms of resistance to venetoclax and strategies to circumvent it. 2017 Jun 2 1
19 28847998 Promising efficacy and acceptable safety of venetoclax plus bortezomib and dexamethasone in relapsed/refractory MM. 2017 Nov 30 1
20 29018077 Efficacy of venetoclax as targeted therapy for relapsed/refractory t(11;14) multiple myeloma. 2017 Nov 30 1
21 29263915 Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells. 2017 1
22 26939706 Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models. 2016 May 3
23 27056887 High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition. 2016 May 10 3
24 27095788 BCR signaling inhibitors differ in their ability to overcome Mcl-1-mediated resistance of CLL B cells to ABT-199. 2016 Jun 23 1
25 26565405 Loss in MCL-1 function sensitizes non-Hodgkin's lymphoma cell lines to the BCL-2-selective inhibitor venetoclax (ABT-199). 2015 Nov 13 1