Title : Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells.

Pub. Date : 2020 May 14

PMID : 32184020






1 Functional Relationships(s)
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1 AZD5991 exhibited the synergistic action with PNT, anti-cancer drugs and venetoclax (BCL2 inhibitor), suggesting the utility of MCL1 inhibitor alone or in combination as a future clinical option for Ph + leukemia patients. venetoclax MCL1 apoptosis regulator, BCL2 family member Homo sapiens