2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

MCL1 apoptosis regulator, BCL2 family member ; Homo sapiens







19 Article(s)
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1 31827702 Enhancement of Quercetin-Induced Apoptosis by Cotreatment with Autophagy Inhibitor Is Associated with Augmentation of BAK-Dependent Mitochondrial Pathway in Jurkat T Cells. 2019 1
2 27007368 Isoquercitrin Inhibits Hydrogen Peroxide-Induced Apoptosis of EA.hy926 Cells via the PI3K/Akt/GSK3β Signaling Pathway. 2016 Mar 21 2
3 27465322 Mcl-1 as a potential therapeutic target for human hepatocelluar carcinoma. 2016 Aug 1
4 27586274 Inhibition of autophagy enhances dynamin inhibitor-induced apoptosis via promoting Bak activation and mitochondrial damage in human Jurkat T cells. 2016 Sep 30 1
5 25903972 In Vitro Assessment of the Anticancer Potential of Evodiamine in Human Oral Cancer Cell Lines. 2015 Aug 1
6 24556678 Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L). 2014 Feb 20 1
7 23909734 Triticuside A, a dietary flavonoid, inhibits proliferation of human breast cancer cells via inducing apoptosis. 2013 1
8 22581584 ADAM10 overexpression confers resistance to doxorubicin-induced apoptosis in hepatocellular carcinoma. 2012 Oct 1
9 15626746 Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides. 2005 Apr 15 1
10 14999683 Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt. 2004 Mar 1
11 12879014 Selective activation of the c-Jun N-terminal kinase (JNK) pathway fails to elicit Bax activation or apoptosis unless the phosphoinositide 3'-kinase (PI3K) pathway is inhibited. 2003 Jul 24 1
12 12393602 Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta. 2002 Nov 15 1
13 12445202 The phosphotidyl inositol 3-kinase/Akt signal pathway is involved in interleukin-6-mediated Mcl-1 upregulation and anti-apoptosis activity in basal cell carcinoma cells. 2002 Nov 2
14 12606824 Betulinic acid-induced Mcl-1 expression in human melanoma--mode of action and functional significance. 2002 Dec 2
15 11314001 The involvement of PI 3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6. 2001 Feb 8 1
16 11457886 Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation. 2001 Jul 16 1
17 11585835 Cyclooxygenase-2 inducing Mcl-1-dependent survival mechanism in human lung adenocarcinoma CL1.0 cells. Involvement of phosphatidylinositol 3-kinase/Akt pathway. 2001 Dec 28 2
18 11593385 The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of Mcl-1 through a PI 3-K/Akt pathway. 2001 Sep 13 1
19 10961875 Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways. 2000 Sep 1 1