Title : Enhancement of Quercetin-Induced Apoptosis by Cotreatment with Autophagy Inhibitor Is Associated with Augmentation of BAK-Dependent Mitochondrial Pathway in Jurkat T Cells.

Pub. Date : 2019

PMID : 31827702






1 Functional Relationships(s)
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1 Cotreatment with the autophagy inhibitor (3-methyladenine, LY294002, or chloroquine) resulted in a significant enhancement of quercetin-induced BAK activation and subsequently the mitochondrial damage-mediated apoptosis pathway by augmenting the downregulation of BAG3 and MCL-1 levels in J/Neo cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one MCL1 apoptosis regulator, BCL2 family member Homo sapiens