Leucine

solute carrier family 7 member 5 ; Homo sapiens







68 Article(s)
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1 34427144 Analysis of L-leucine amino acid transporter species activity and gene expression by human blood brain barrier hCMEC/D3 model reveal potential LAT1, LAT4, B0AT2 and y+LAT1 functional cooperation. 2022 Jan 4
2 35379539 Phenylketonuria oxidative stress and energy dysregulation: Emerging pathophysiological elements provide interventional opportunity. 2022 Jun 2
3 35408997 Functional Characterization of the Solute Carrier LAT-1 (SLC7A5/SLC2A3) in Human Brain Capillary Endothelial Cells with Rapid UPLC-MS/MS Quantification of Intracellular Isotopically Labelled L-Leucine. 2022 Mar 26 8
4 35431492 Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis. 2022 Mar 14 1
5 35501367 Polarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in ER+ breast cancer. 2022 May 2 1
6 33011235 Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5). 2021 Jan 1 1
7 33401672 The Harmonious Interplay of Amino Acid and Monocarboxylate Transporters Induces the Robustness of Cancer Cells. 2021 Jan 2 2
8 33758168 Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter. 2021 Mar 23 1
9 33953707 Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor Microenvironment. 2021 1
10 33964466 Counter-directed leucine gradient promotes amino acid transfer across the human placenta. 2021 Oct 3
11 34145066 Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals. 2021 Jun 18 1
12 34152720 Baicalein Delays H2O2-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism. 2021 Jul 7 2
13 34194623 Oncogenic transformation of NIH/3T3 cells by the overexpression of L-type amino acid transporter 1, a promising anti-cancer target. 2021 Jun 22 1
14 34201429 The Adipose Tissue-Derived Secretome (ADS) in Obesity Uniquely Induces L-Type Amino Acid Transporter 1 (LAT1) and mTOR Signaling in Estrogen-Receptor-Positive Breast Cancer Cells. 2021 Jun 23 4
15 34349180 Acetylation turns leucine into a drug by membrane transporter switching. 2021 Aug 4 6
16 34503187 Targeting Amino Acid Metabolic Reprogramming via L-Type Amino Acid Transporter 1 (LAT1) for Endocrine-Resistant Breast Cancer. 2021 Aug 30 2
17 34836160 LAT1 and SNAT2 Protein Expression and Membrane Localization of LAT1 Are Not Acutely Altered by Dietary Amino Acids or Resistance Exercise Nor Positively Associated with Leucine or Phenylalanine Incorporation in Human Skeletal Muscle. 2021 Oct 30 1
18 31992742 Expression of L-type amino acid transporter 1 as a molecular target for prognostic and therapeutic indicators in bladder carcinoma. 2020 Jan 28 2
19 33001560 Small molecule inhibitors provide insights into the relevance of LAT1 and LAT2 in materno-foetal amino acid transport. 2020 Nov 4
20 33521042 LAT1 Protein Content Increases Following 12 Weeks of Resistance Exercise Training in Human Skeletal Muscle. 2020 1
21 30092695 l-Leucine influx through Slc7a5 regulates inflammatory responses of human B cells via mammalian target of rapamycin complex 1 signaling. 2019 Sep 2
22 30696773 Interleukin-18 up-regulates amino acid transporters and facilitates amino acid-induced mTORC1 activation in natural killer cells. 2019 Mar 22 2
23 30996345 LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer. 2019 May 4
24 31160781 Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc. 2019 Jun 1
25 28856713 Leucine supplementation after mechanical stimulation activates protein synthesis via L-type amino acid transporter 1 in vitro. 2018 Feb 4
26 29150487 Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin. 2018 Jan 4 5
27 29422900 Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte/Macrophage Immune Responses. 2018 2
28 29695141 Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1. 2018 Apr 24 2
29 29940911 Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways. 2018 Jun 26 3
30 30029480 Targeted Suppression and Knockout of ASCT2 or LAT1 in Epithelial and Mesenchymal Human Liver Cancer Cells Fail to Inhibit Growth. 2018 Jul 19 2
31 30449824 L-Type Amino Acid Transporter 1 Immunoreactivity as a Possible Diagnostic and Prognostic Marker of Thymic Carcinoma. 2018 Nov 2
32 28242177 Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1). 2017 Feb 1
33 28516268 GPNA inhibits the sodium-independent transport system L for neutral amino acids. 2017 Aug 1
34 29278358 Characterisation of L-Type Amino Acid Transporter 1 (LAT1) Expression in Human Skeletal Muscle by Immunofluorescent Microscopy. 2017 Dec 26 2
35 26621329 Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells. 2016 Jan 1 1
36 26682754 Up-Regulation of LAT1 during Antiandrogen Therapy Contributes to Progression in Prostate Cancer Cells. 2016 May 2
37 26724922 Structure-activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling. 2016 Apr 4
38 26944194 Aryl hydrocarbon receptor (AHR) regulation of L-Type Amino Acid Transporter 1 (LAT-1) expression in MCF-7 and MDA-MB-231 breast cancer cells. 2016 Apr 15 1
39 27412117 Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure. 2016 Oct 1
40 27486861 LAT1 is a putative therapeutic target in endometrioid endometrial carcinoma. 2016 Dec 1 2
41 27567475 LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells. 2016 Nov 3
42 25613922 Metabolic and molecular responses to leucine-enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis. 2015 Jun 1
43 25998567 LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation. 2015 May 22 2
44 26101697 L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. 2015 2
45 26668776 The role of L-type amino acid transporter 1 in human tumors. 2015 Nov 2
46 22898570 Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism. 2013 May 1
47 22985970 Upregulation of amino acid transporter expression induced by L-leucine availability in L6 myotubes is associated with ATF4 signaling through mTORC1-dependent mechanism. 2013 Jan 2
48 23525088 Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. 2013 May 1
49 23896327 L-type amino acid transporter 1 (LAT1): a new therapeutic target for canine mammary gland tumour. 2013 Oct 1
50 23954667 A new treatment for human malignant melanoma targeting L-type amino acid transporter 1 (LAT1): a pilot study in a canine model. 2013 Sep 13 1