Title : Targeted Suppression and Knockout of ASCT2 or LAT1 in Epithelial and Mesenchymal Human Liver Cancer Cells Fail to Inhibit Growth.

Pub. Date : 2018 Jul 19

PMID : 30029480






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Both approaches successfully diminished glutamine (ASCT2) and leucine (LAT1) initial-rate transport proportional to transporter protein suppression. Leucine solute carrier family 7 member 5 Homo sapiens
2 However, intracellular accumulation of radiolabeled glutamine and leucine over longer time periods largely recovered to control levels in ASCT2 and LAT1 knockout cells, respectively, which partially explains the lack of an impaired growth phenotype. Leucine solute carrier family 7 member 5 Homo sapiens