Title : Upregulation of amino acid transporter expression induced by L-leucine availability in L6 myotubes is associated with ATF4 signaling through mTORC1-dependent mechanism.

Pub. Date : 2013 Jan

PMID : 22985970






2 Functional Relationships(s)
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1 METHODS: L6 skeletal muscle cells that had been treated with l-leucine (0.105 g/L) were incubated for 30 min to stimulate the transcription of L-type amino acid transporter-1, CD98, and sodium-coupled neutral amino acid transporter-2 and increase activating transcription factor-4 protein, which is dependent on the mTORC1 signaling pathway. Leucine solute carrier family 7 member 5 Homo sapiens
2 METHODS: L6 skeletal muscle cells that had been treated with l-leucine (0.105 g/L) were incubated for 30 min to stimulate the transcription of L-type amino acid transporter-1, CD98, and sodium-coupled neutral amino acid transporter-2 and increase activating transcription factor-4 protein, which is dependent on the mTORC1 signaling pathway. Leucine solute carrier family 7 member 5 Homo sapiens