Guanosine Triphosphate

eukaryotic translation initiation factor 2 subunit beta ; Homo sapiens







106 Article(s)
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1 34923394 Dynamic interaction network involving the conserved intrinsically disordered regions in human eIF5. 2022 Feb 1
2 35171475 Quantifying the Binding of Fluorescently Labeled Guanine Nucleotides and Initiator tRNA to Eukaryotic Translation Initiation Factor 2. 2022 6
3 34877508 GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity. 2021 Dec 17 1
4 30576497 A network of eIF2β interactions with eIF1 and Met-tRNAi promotes accurate start codon selection by the translation preinitiation complex. 2019 Mar 18 1
5 31048492 Structural basis for eIF2B inhibition in integrated stress response. 2019 May 3 1
6 29425030 eIF2B Mechanisms of Action and Regulation: A Thermodynamic View. 2018 Mar 6 1
7 29666249 eIF1 Loop 2 interactions with Met-tRNAi control the accuracy of start codon selection by the scanning preinitiation complex. 2018 May 1 2
8 30211544 Human eIF5 and eIF1A Compete for Binding to eIF5B. 2018 Oct 9 2
9 30281470 Modeling and Dynamic Behavior of eIF2 Dependent Regulatory System With Disturbances. 2018 Oct 1
10 29036434 Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation. 2017 Nov 16 4
11 26705305 Moco biosynthesis and the ATAC acetyltransferase engage translation initiation by inhibiting latent PKR activity. 2016 Feb 2
12 26717981 Sliding of a 43S ribosomal complex from the recognized AUG codon triggered by a delay in eIF2-bound GTP hydrolysis. 2016 Feb 29 2
13 25762631 Depletion of eIF2·GTP·Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo. 2015 Mar 30 1
14 24335188 Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy. 2014 Feb 4
15 24499181 The scanning mechanism of eukaryotic translation initiation. 2014 2
16 25486352 A new function and complexity for protein translation initiation factor eIF2B. 2014 1
17 24095748 Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors. 2013 Nov 2
18 22683627 The binding mechanism of eIF2β with its partner proteins, eIF5 and eIF2Bε. 2012 Jul 6 2
19 19808042 A mechanistic model of nutritional control of protein synthesis in animal tissues. 2010 Jan 21 1
20 20048003 Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome. 2010 Jan 1 1
21 20485439 eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation. 2010 May 20 1
22 21204011 Crystal structure of the C-terminal domain of the ɛ subunit of human translation initiation factor eIF2B. 2010 Jun 3
23 19835415 How does a scanning ribosomal particle move along the 5'-untranslated region of eukaryotic mRNA? Brownian Ratchet model. 2009 Nov 17 1
24 18160716 A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B. 2008 Mar 1
25 18631136 Clues to the mechanism of action of eIF2B, the guanine-nucleotide-exchange factor for translation initiation. 2008 Aug 2
26 18639529 Intersubunit and interprotein interactions of alpha- and beta-subunits of human eIF2: Effect of phosphorylation. 2008 Sep 19 1
27 17923239 Identifying small molecule inhibitors of eukaryotic translation initiation. 2007 1
28 16362046 The fidelity of translation initiation: reciprocal activities of eIF1, IF3 and YciH. 2006 Jan 11 1
29 16461768 Interaction between eukaryotic initiation factors 1A and 5B is required for efficient ribosomal subunit joining. 2006 Mar 31 1
30 16582624 Localization of the translational guanine nucleotide exchange factor eIF2B: a common theme for GEFs? 2006 Apr 2
31 16584190 Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors. 2006 Apr 11 2
32 16924118 Structure of archaeal translational initiation factor 2 betagamma-GDP reveals significant conformational change of the beta-subunit and switch 1 region. 2006 Aug 29 1
33 16928960 Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. 2006 Nov 2
34 16973618 Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56. 2006 Nov 10 1
35 16990799 An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation. 2006 Oct 4 2
36 16157703 Dynamic cycling of eIF2 through a large eIF2B-containing cytoplasmic body: implications for translation control. 2005 Sep 12 2
37 16193068 The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo. 2005 Oct 19 2
38 16246087 Alternative mechanisms of initiating translation of mammalian mRNAs. 2005 Dec 1
39 14681227 Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residue. 2004 Mar 12 1
40 15145951 Efficient incorporation of eukaryotic initiation factor 1 into the multifactor complex is critical for formation of functional ribosomal preinitiation complexes in vivo. 2004 Jul 23 1
41 15277680 Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. 2004 Aug 3 2
42 15601822 Release of initiation factors from 48S complexes during ribosomal subunit joining and the link between establishment of codon-anticodon base-pairing and hydrolysis of eIF2-bound GTP. 2004 Dec 15 5
43 12493757 Mammalian translation initiation factor eIF1 functions with eIF1A and eIF3 in the formation of a stable 40 S preinitiation complex. 2003 Feb 21 2
44 12514125 Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo. 2003 Jan 15 1
45 12885778 Viral stress-inducible protein p56 inhibits translation by blocking the interaction of eIF3 with the ternary complex eIF2.GTP.Met-tRNAi. 2003 Oct 10 2
46 11859078 Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha. 2002 May 10 1
47 11861906 Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in vivo. 2002 Mar 1 2
48 11166181 Eukaryotic translation initiation factor 5 (eIF5) acts as a classical GTPase-activator protein. 2001 Jan 9 1
49 11323413 Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein. 2001 Jul 6 1
50 11726195 Catalysis of guanine nucleotide exchange on eIF2 by eIF2B: can it be both a substituted enzyme and a sequential mechanism? 2001 Dec 7 1