Title : Mammalian translation initiation factor eIF1 functions with eIF1A and eIF3 in the formation of a stable 40 S preinitiation complex.

Pub. Date : 2003 Feb 21

PMID : 12493757






2 Functional Relationships(s)
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1 We have examined the role of the mammalian initiation factor eIF1 in the formation of the 40 S preinitiation complex using in vitro binding of initiator Met-tRNA (as Met-tRNA(i).eIF2.GTP ternary complex) to 40 S ribosomal subunits in the absence of mRNA. Guanosine Triphosphate eukaryotic translation initiation factor 2 subunit beta Homo sapiens
2 These three initiation factors also bind to free 40 S subunits, and the resulting complex can act as an acceptor of the ternary complex to form the 40 S preinitiation complex (40 S.eIF3.eIF1.eIF1A.Met-tRNA(i).eIF2.GTP). Guanosine Triphosphate eukaryotic translation initiation factor 2 subunit beta Homo sapiens