Title : Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors.

Pub. Date : 2013 Nov

PMID : 24095748






2 Functional Relationships(s)
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1 Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2 GTP Met-tRNAiMet ternary complex inhibitors. Guanosine Triphosphate eukaryotic translation initiation factor 2 subunit beta Homo sapiens
2 The 3,3-diaryloxindoles were recently reported as potential inhibitors of the eIF2 GTP Met-tRNAi(Met) ternary complex assembly and 3-{5-tert-butyl-2-hydroxyphenyl}-3-phenyl-1,3-dihydro-2H-indol-2-one #1181 was identified as the prototypic agent of this chemotype. Guanosine Triphosphate eukaryotic translation initiation factor 2 subunit beta Homo sapiens