Title : Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners.

Pub. Date : 2011 Jan-Feb

PMID : 21345291






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this study, we have investigated the mechanism by which simvastatin inhibits the production of the mediators of inflammation, such as pentraxin 3 (PTX3) and monocyte chemoattractant protein-1 (MCP-1), from fibroblast-like synoviocytes (FLS) derived from patients with RA. Simvastatin C-C motif chemokine ligand 2 Homo sapiens
2 In this study, we have investigated the mechanism by which simvastatin inhibits the production of the mediators of inflammation, such as pentraxin 3 (PTX3) and monocyte chemoattractant protein-1 (MCP-1), from fibroblast-like synoviocytes (FLS) derived from patients with RA. Simvastatin C-C motif chemokine ligand 2 Homo sapiens
3 RESULTS: Simvastatin both reduced the secretion of PTX3 and MCP-1 in FLS cultures and inhibited their mRNA expression in these cells. Simvastatin C-C motif chemokine ligand 2 Homo sapiens
4 CONCLUSIONS: Although simvastatin inhibited the production of PTX3 and MCP-1 in RA FLS, the mechanisms were quite different. Simvastatin C-C motif chemokine ligand 2 Homo sapiens