Tyrosine

SHC adaptor protein 1 ; Homo sapiens







402 Article(s)
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1 35072342 Cell fate-inducing CARs orthogonally control multiple signaling pathways. 2022 May 1
2 34157521 Epidermal growth factor receptor and integrins meet redox signaling through P66shc and Rac1. 2021 Oct 2
3 31820037 Elucidation of protein interactions necessary for the maintenance of the BCR-ABL signaling complex. 2020 Oct 1
4 31974654 A SYK/SHC1 pathway regulates the amount of CFTR in the plasma membrane. 2020 Dec 2
5 32299913 The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation. 2020 Jul 31 4
6 31695561 Ginsenoside Rg1 activates ligand-independent estrogenic effects via rapid estrogen receptor signaling pathway. 2019 Oct 1
7 29018139 ShcA Adaptor Protein Promotes Nephrin Endocytosis and Is Upregulated in Proteinuric Nephropathies. 2018 Jan 2
8 29453318 Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance. 2018 May 8
9 28690151 Identification of STS-1 as a novel ShcA-binding protein. 2017 Sep 2 2
10 27456487 FcγRIIB-Independent Mechanisms Controlling Membrane Localization of the Inhibitory Phosphatase SHIP in Human B Cells. 2016 Sep 1 1
11 27543756 Role of Herpes simplex virus 1 VP11/12 tyrosine-based binding motifs for Src family kinases, p85, Grb2 and Shc in activation of the phosphoinositide 3-kinase-Akt pathway. 2016 Nov 2
12 27605668 Up-regulation of N-cadherin by Collagen I-activated Discoidin Domain Receptor 1 in Pancreatic Cancer Requires the Adaptor Molecule Shc1. 2016 Oct 28 2
13 25893141 Phospho-Tyrosine(s) vs. Phosphatidylinositol Binding in Shc Mediated Integrin Signaling. 2015 Apr 1
14 26680585 ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation. 2015 Dec 1
15 24795043 Adapter protein Shc regulates Janus kinase 3 phosphorylation. 2014 Jun 6 4
16 23277357 Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor β (TGFβ)-induced breast cancer cell migration, invasion, and metastasis. 2013 Feb 15 10
17 23457259 The insulin receptor: both a prototypical and atypical receptor tyrosine kinase. 2013 Mar 1 1
18 23946459 Role of herpes simplex virus VP11/12 tyrosine-based motifs in binding and activation of the Src family kinase Lck and recruitment of p85, Grb2, and Shc. 2013 Oct 2
19 22683472 Effect of EGF-receptor tyrosine kinase inhibitor on Rab5 function during endocytosis. 2012 Sep 1 1
20 21454706 Differential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptor. 2011 May 13 1
21 22328908 Insights into structure and function of SHIP2-SH2: homology modeling, docking, and molecular dynamics study. 2011 Oct 1
22 19826412 Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarity. 2010 Jan 14 1
23 20175207 The fibroblast growth factor receptor (FGFR) agonist FGF1 and the neural cell adhesion molecule-derived peptide FGL activate FGFR substrate 2alpha differently. 2010 Jul 1
24 20498373 Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth. 2010 Jul 30 1
25 20739287 Integrin {beta}3 phosphorylation dictates its complex with the Shc phosphotyrosine-binding (PTB) domain. 2010 Nov 5 2
26 24281038 Increased Level of Phosphorylated ShcA Measured by Chemiluminescence-Linked Immunoassay Is a Predictor of Good Prognosis in Primary Breast Cancer Expressing Low Levels of Estrogen Receptor. 2010 Mar 12 1
27 19001530 A novel role of Shc adaptor proteins in steroid hormone-regulated cancers. 2009 Mar 4
28 19229850 CD247 can bind SHC1, no matter if CD247 is phosphorylated. 2009 May-Jun 7
29 19289054 Molecular dynamics simulations reveal that Tyr-317 phosphorylation reduces Shc binding affinity for phosphotyrosyl residues of epidermal growth factor receptor. 2009 Mar 18 8
30 19798056 Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor. 2009 Nov 18 2
31 17607710 Expression of the human beta3 integrin subunit in mouse smooth muscle cells enhances IGF-I-stimulated signaling and proliferation. 2008 Feb 3
32 18036576 Interleukin-1beta interferes with signal transduction induced by neurotrophin-3 in cortical neurons. 2008 Jan 10 1
33 18279888 A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein. 2008 Mar 28 1
34 18292237 Glucose regulation of integrin-associated protein cleavage controls the response of vascular smooth muscle cells to insulin-like growth factor-I. 2008 May 1
35 18332126 Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion. 2008 May 2
36 18353552 Subcellular receptor redistribution and enhanced microspike formation by a Ret receptor preferentially recruiting Dok. 2008 Apr 11 1
37 17219406 Regulation of PDGF-stimulated SHIP2 tyrosine phosphorylation and association with Shc in 3T3-L1 preadipocytes. 2007 Jun 1
38 17329403 Angiotensin II type 2 receptor-dependent increases in nitric oxide synthase expression in the pulmonary endothelium is mediated via a G alpha i3/Ras/Raf/MAPK pathway. 2007 Jun 1
39 17346182 The IGF-I signaling pathway. 2007 1
40 17673906 TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. 2007 Sep 5 1
41 17705384 Using measurements of anchoring energies of liquid crystals on surfaces to quantify proteins captured by immobilized ligands. 2007 Sep 12 1
42 17908971 p66 Shc tumor levels show a strong prognostic correlation with disease outcome in stage IIA colon cancer. 2007 Oct 1 2
43 16241905 Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling. 2006 Mar 15 1
44 16436505 HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway. 2006 Apr 1
45 16477370 Expression of the ErbB4 receptor causes reversal regulation of PP2A in the Shc signal transduction pathway in human cancer cells. 2006 Apr 2
46 16573649 The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor. 2006 May 1
47 16847065 Engineering the recruitment of phosphotyrosine binding domain-containing adaptor proteins reveals distinct roles for RET receptor-mediated cell survival. 2006 Oct 6 1
48 17158797 Polyoma and SV40 proteins differentially regulate PP2A to activate distinct cellular signaling pathways involved in growth control. 2006 Dec 19 1
49 17196107 p66 Shc and tyrosine-phosphorylated Shc in primary breast tumors identify patients likely to relapse despite tamoxifen therapy. 2006 4
50 17384289 Amyloid precursor protein modulates ERK-1 and -2 signaling. 2006 Dec 1