Title : A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein.

Pub. Date : 2008 Mar 28

PMID : 18279888






1 Functional Relationships(s)
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1 Thus, Shc has an intrinsic phosphorylation-dependent gating mechanism where the SH2 domain adopts an open conformation only when tyrosine phosphorylation has occurred. Tyrosine SHC adaptor protein 1 Homo sapiens