| 1 |
34666128 | Baicalein protects against MPP+/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson's disease. | 2021 Dec |
2 |
| 2 |
30738894 | Regulation of Monoamine Oxidase B Gene Expression: Key Roles for Transcription Factors Sp1, Egr1 and CREB, and microRNAs miR-300 and miR-1224. | 2019 Mar 15 |
2 |
| 3 |
29498006 | Inhibition of Cyclooxygenase-2 (COX-2) Initiates Autophagy and Potentiates MPTP-Induced Autophagic Cell Death of Human Neuroblastoma Cells, SH-SY5Y: an Inside in the Pathology of Parkinson's Disease. | 2018 Oct |
2 |
| 4 |
27523294 | N-methyltetrahydropyridines and pyridinium cations as toxins and comparison with naturally-occurring alkaloids. | 2016 Nov |
2 |
| 5 |
27882077 | Potential protective effects of autophagy activated in MPP+ treated astrocytes. | 2016 Nov |
1 |
| 6 |
25677185 | Design and synthesis of a MAO-B-selectively activated prodrug based on MPTP: a mitochondria-targeting chemotherapeutic agent for treatment of human malignant gliomas. | 2015 Apr |
2 |
| 7 |
21992679 | Evaluation of the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic pyridinium cations by monoamine oxidase (MAO) enzymes and its use to search for new MAO inhibitors and protective agents. | 2012 Dec |
2 |
| 8 |
23231395 | Type A and B monoamine oxidase in age-related neurodegenerative disorders: their distinct roles in neuronal death and survival. | 2012 |
2 |
| 9 |
21277784 | Reaction of benzophenone triplet with aliphatic amines. What a potent neurotoxin can tell us about the reaction mechanism. | 2011 Feb 15 |
1 |
| 10 |
21554916 | Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors. | 2011 Aug |
2 |
| 11 |
21971004 | Type A monoamine oxidase regulates life and death of neurons in neurodegeneration and neuroprotection. | 2011 |
1 |
| 12 |
19669997 | Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO). | 2009 Oct |
4 |
| 13 |
18065227 | Structure-activity relationships in the inhibition of monoamine oxidase B by 1-methyl-3-phenylpyrroles. | 2008 Mar 1 |
6 |
| 14 |
18313306 | Stereochemical studies on the novel monoamine oxidase B substrates (1R,6S)- and (1S,6R)-3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane. | 2008 Apr 1 |
2 |
| 15 |
18713667 | The tert-butoxyl radical mediated hydrogen atom transfer reactions of the Parkinsonian proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and selected tertiary amines. | 2008 Sep 15 |
2 |
| 16 |
18840519 | Catalpol protects mesencephalic neurons against MPTP induced neurotoxicity via attenuation of mitochondrial dysfunction and MAO-B activity. | 2008 Dec |
2 |
| 17 |
16870220 | Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6. | 2006 Nov 1 |
3 |
| 18 |
16985099 | Metabolic aromatization of N-alkyl-1,2,3,4-tetrahydroquinoline substructures to quinolinium by human liver microsomes and horseradish peroxidase. | 2006 Dec |
1 |
| 19 |
17447416 | Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson's disease: possible implications of glial cells. | 2006 |
2 |
| 20 |
16099847 | Role of the redox protein thioredoxin in cytoprotective mechanism evoked by (-)-deprenyl. | 2005 Nov |
4 |
| 21 |
14697898 | (-)-Deprenyl, a selective MAO-B inhibitor, with apoptotic and anti-apoptotic properties. | 2004 Jan |
1 |
| 22 |
14962063 | Effect of melatonin on temporal changes of reactive oxygen species and glutathione after MPP(+) treatment in human astrocytoma U373MG cells. | 2004 Mar |
1 |
| 23 |
12427476 | PF 9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine], a new MAO-B inhibitor, attenuates MPTP-induced depletion of striatal dopamine levels in C57/BL6 mice. | 2003 Feb |
2 |
| 24 |
12044541 | Role of hydroxyl radical formation in neurotoxicity as revealed by in vivo free radical trapping. | 2002 Jun 14 |
1 |
| 25 |
12866710 | Endogenous risk factors in Parkinson's disease: dopamine and tetrahydroisoquinolines. | 2002 Nov-Dec |
2 |
| 26 |
11008487 | Molecular characterization of monoamine oxidases A and B. | 2001 |
2 |
| 27 |
11172770 | SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. | 2001 Feb 23 |
2 |
| 28 |
11233301 | [Parkinsonism induced by MPTP and free radical generation]. | 2001 Feb |
1 |
| 29 |
11090954 | Cell death induced by MPTP, a substrate for monoamine oxidase B. | 2000 Nov 16 |
2 |
| 30 |
16787846 | Neuroprotective strategies in Parkinson's disease: protection against progressive nigral damage induced by free radicals. | 2000 |
1 |
| 31 |
10218814 | Synthesis and MAO-B substrate properties of 1-methyl-4-heteroaryl-1,2,3,6-tetrahydropyridines. | 1999 Feb |
4 |
| 32 |
10658587 | Synthesis and monoamine oxidase B substrate properties of 1-methyl-4-heteroaryl-1,2,3,6-tetrahydropyridines. | 1999 Dec |
1 |
| 33 |
9109551 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) decreases glutamate uptake in cultured astrocytes. | 1997 May |
1 |
| 34 |
9305573 | Potential metabolic bioactivation pathways involving cyclic tertiary amines and azaarenes. | 1997 Sep |
1 |
| 35 |
9359458 | Isoquinoline neurotoxins in the brain and Parkinson's disease. | 1997 Oct |
4 |
| 36 |
8627546 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease. | 1996 May |
2 |
| 37 |
8809158 | Assessment of structural requirements for the monoamine oxidase-B-catalyzed oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridine derivatives related to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. | 1996 Sep 13 |
1 |
| 38 |
8959985 | Oxidative stress and the pathogenesis of Parkinson's disease. | 1996 Dec |
1 |
| 39 |
7548753 | Probing the mechanism of bioactivation of MPTP type analogs by monoamine oxidase B: structure-activity studies on substituted 4-phenoxy-, 4-phenyl-, and 4-thiophenoxy-1-cyclopropyl-1,2,3,6-tetrahydropyridines. | 1995 Jul-Aug |
1 |
| 40 |
7756620 | Selective suppression of type B monoamine oxidase immunoreactivity in the raphe nuclei following MPTP administration in the cat. | 1995 Jan 26 |
3 |
| 41 |
7828725 | Inhibition of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolic activity of porcine FAD-containing monooxygenase by selective monoamine oxidase-B inhibitors. | 1995 Jan 23 |
1 |
| 42 |
7995015 | Biochemical actions of l-deprenyl (selegiline). | 1994 Dec |
2 |
| 43 |
8158148 | Oxidation products arising from the action of monoamine oxidase B on 1-methyl-4-benzyl-1,2,3,6-tetrahydropyridine, a nonneurotoxic analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. | 1994 May |
1 |
| 44 |
8393868 | Generation of reactive oxygen species during the monoamine oxidase-catalyzed oxidation of the neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. | 1993 Aug 5 |
7 |
| 45 |
8452568 | An investigation into the role of reactive oxygen species in the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity using neuronal cell lines. | 1993 Feb 24 |
2 |
| 46 |
8487265 | Molecular size and flexibility as determinants of selectivity in the oxidation of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs by monoamine oxidase A and B. | 1993 Apr 30 |
4 |
| 47 |
8489207 | Association of a monoamine oxidase B allele with Parkinson's disease. | 1993 Apr |
2 |
| 48 |
1417423 | [Experimental model of Parkinson disease: mechanisms and anatomo- pathological characteristics of MPTP neurotoxicity]. | 1992 Jul-Aug |
1 |
| 49 |
1433219 | Synthesis of novel MPTP analogs as potential monoamine oxidase B (MAO-B) inhibitors. | 1992 Oct 30 |
5 |
| 50 |
1446001 | Studies on 1,2,3,6-tetrahydropyridine derivatives as potential monoamine oxidase inactivators. | 1992 Sep-Oct |
3 |