Title : Synthesis and MAO-B substrate properties of 1-methyl-4-heteroaryl-1,2,3,6-tetrahydropyridines.

Pub. Date : 1999 Feb

PMID : 10218814






4 Functional Relationships(s)
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1 The parkinsonian inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is bioactivated in a reaction catalyzed by the flavoenzyme monoamine oxidase B (MAO-B) to form the corresponding dihydropyridinium and subsequently pyridinium metabolites. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine monoamine oxidase B Homo sapiens
2 The parkinsonian inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is bioactivated in a reaction catalyzed by the flavoenzyme monoamine oxidase B (MAO-B) to form the corresponding dihydropyridinium and subsequently pyridinium metabolites. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine monoamine oxidase B Homo sapiens
3 The parkinsonian inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is bioactivated in a reaction catalyzed by the flavoenzyme monoamine oxidase B (MAO-B) to form the corresponding dihydropyridinium and subsequently pyridinium metabolites. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine monoamine oxidase B Homo sapiens
4 The parkinsonian inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is bioactivated in a reaction catalyzed by the flavoenzyme monoamine oxidase B (MAO-B) to form the corresponding dihydropyridinium and subsequently pyridinium metabolites. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine monoamine oxidase B Homo sapiens