Temozolomide

O-6-methylguanine-DNA methyltransferase ; Homo sapiens







746 Article(s)
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1 34016221 Evaluation of MGMT Gene Methylation in Neuroendocrine Neoplasms. 2022 Jan 31 2
2 34625658 Pharmacological inhibition of serine synthesis enhances temozolomide efficacy by decreasing O6-methylguanine DNA methyltransferase (MGMT) expression and reactive oxygen species (ROS)-mediated DNA damage in glioblastoma. 2022 Feb 2
3 34731767 Acridine-O6-benzylguanine hybrids: Synthesis, DNA binding, MGMT inhibition and antiproliferative activity. 2022 Jan 5 4
4 34967073 CN-3 increases TMZ sensitivity and induces ROS-dependent apoptosis and autophagy in TMZ-resistance glioblastoma. 2022 Mar 3
5 34969742 Association of MGMT Gene Promoter Methylation With Clinicopathological Parameters in Patients With Wild-type IDH Glioblastoma. 2022 Jan 2
6 34976195 Clinical strategies to manage adult glioblastoma patients without MGMT hypermethylation. 2022 3
7 34982371 The effect of levetiracetam treatment on survival in patients with glioblastoma: a systematic review and meta-analysis. 2022 Jan 4
8 35045869 Phase I/II trial of meclofenamate in progressive MGMT-methylated glioblastoma under temozolomide second-line therapy-the MecMeth/NOA-24 trial. 2022 Jan 19 1
9 35061210 High-risk pituitary adenomas and strategies for predicting response to treatment. 2022 Mar 1
10 35119837 Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture. 2022 Feb 18 2
11 35122621 Newly Diagnosed Glioblastoma in Elderly Patients. 2022 Mar 1
12 35145081 Acquired temozolomide resistance in MGMTlow gliomas is associated with regulation of homologous recombination repair by ROCK2. 2022 Feb 10 1
13 35163465 Up-Regulation of Cyclooxygenase-2 (COX-2) Expression by Temozolomide (TMZ) in Human Glioblastoma (GBM) Cell Lines. 2022 Jan 28 5
14 35173295 Synergy between TMZ and individualized multimodal immunotherapy to improve overall survival of IDH1 wild-type MGMT promoter-unmethylated GBM patients. 2022 Feb 16 1
15 35180887 Bisulfite profiling of the MGMT promoter and comparison with routine testing in glioblastoma diagnostics. 2022 Feb 18 1
16 35187626 Recycling of SLC38A1 to the plasma membrane by DSCR3 promotes acquired temozolomide resistance in glioblastoma. 2022 Mar 6
17 35205800 Interstitial Control-Released Polymer Carrying a Targeting Small-Molecule Drug Reduces PD-L1 and MGMT Expression in Recurrent High-Grade Gliomas with TMZ Resistance. 2022 Feb 18 6
18 35258987 Temozolomide Followed by Combination With Low-Dose Ipilimumab and Nivolumab in Patients With Microsatellite-Stable, O6-Methylguanine-DNA Methyltransferase-Silenced Metastatic Colorectal Cancer: The MAYA Trial. 2022 May 10 4
19 35274103 XAF1 directs glioma response to temozolomide through apoptotic transition of autophagy by activation of ATM-AMPK signaling. 2022 Jan-Dec 1
20 35278900 Tubeimoside-I sensitizes temozolomide-resistant glioblastoma cells to chemotherapy by reducing MGMT expression and suppressing EGFR induced PI3K/Akt/mTOR/NF-κB-mediated signaling pathway. 2022 Feb 27 5
21 35291535 Reclassification of Glioblastoma Multiforme According to the 2021 World Health Organization Classification of Central Nervous System Tumors: A Single Institution Report and Practical Significance. 2022 Feb 1
22 35365623 Class I HDAC overexpression promotes temozolomide resistance in glioma cells by regulating RAD18 expression. 2022 Apr 1 2
23 35372034 A Custom DNA-Based NGS Panel for the Molecular Characterization of Patients With Diffuse Gliomas: Diagnostic and Therapeutic Applications. 2022 2
24 35379142 Temozolomide Resistance: A Multifarious Review on Mechanisms Beyond O‑6‑Methylguanine‑DNA Methyltransferase. 2022 Apr 4 2
25 35388070 Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma. 2022 Apr 6 7
26 35402913 Nivolumab plus radiotherapy with or without temozolomide in newly diagnosed glioblastoma: Results from exploratory phase I cohorts of CheckMate 143. 2022 Jan-Dec 3
27 35419607 Radiotherapy Combined With Nivolumab or Temozolomide for Newly Diagnosed Glioblastoma With Unmethylated MGMT Promoter: An International Randomized Phase 3 Trial. 2022 Apr 14 2
28 35440003 Integrative analysis of therapy resistance and transcriptomic profiling data in glioblastoma cells identifies sensitization vulnerabilities for combined modality radiochemotherapy. 2022 Apr 19 1
29 35452002 PET With 11C-Methyl-l-Methionine as a Predictor of Consequential Outcomes at the Time of Discontinuing Temozolomide-Adjuvant Chemotherapy in Patients With Residual IDH-Mutant Lower-Grade Glioma. 2022 Jul 1 1
30 35453150 Current trend of radiotherapy for glioblastoma in the elderly: a survey study by the brain tumor Committee of the Korean Radiation Oncology Group (KROG 21-05). 2022 Apr 23 1
31 35474499 Survival outcomes associated with MGMT promoter methylation and temozolomide in gliosarcoma patients. 2022 May 4
32 35490896 Mannose inhibits proliferation and promotes apoptosis to enhance sensitivity of glioma cells to temozolomide through Wnt/β-catenin signaling pathway. 2022 Jul 5
33 35491627 Dual Temozolomide and ICI Treatment Is Efficacious and Safe in MSS mCRC. 2022 May 2 1
34 35511454 Phase 3 Trial of Chemoradiotherapy With Temozolomide Plus Nivolumab or Placebo for Newly Diagnosed Glioblastoma With Methylated MGMT Promoter. 2022 May 2 1
35 35511800 Retraction: Enhanced Anti-Tumor Effect of Zoledronic Acid Combined with Temozolomide against Human Malignant Glioma Cell Expressing O6-Methylguanine DNA Methyltransferase. 2022 1
36 35522273 Temozolomide treatment alters mismatch repair and boosts mutational burden in tumor and blood of colorectal cancer patients. 2022 May 6 1
37 35559231 Modified Adenosines Sensitize Glioblastoma Cells to Temozolomide by Affecting DNA Methyltransferases. 2022 3
38 35563629 Effects of Long-Term Temozolomide Treatment on Glioblastoma and Astrocytoma WHO Grade 4 Stem-like Cells. 2022 May 7 7
39 35565362 Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells. 2022 Apr 29 2
40 35566308 Investigating the Stability of Six Phenolic TMZ Ester Analogues, Incubated in the Presence of Porcine Liver Esterase and Monitored by HPLC. 2022 May 5 2
41 35625018 Elderly Gliobastoma Patients: The Impact of Surgery and Adjuvant Treatments on Survival: A Single Institution Experience. 2022 May 11 1
42 32589560 Temozolomide: An Updated Overview of Resistance Mechanisms, Nanotechnology Advances and Clinical Applications. 2021 1
43 32644826 Pulsed and Discontinuous Electromagnetic Field Exposure Decreases Temozolomide Resistance in Glioblastoma by Modulating the Expression of O6-Methylguanine-DNA Methyltransferase, Cyclin-D1, and p53. 2021 Sep 3
44 32710211 MGMT-inhibitor in combination with TGF-βRI inhibitor or CDK 4/6 inhibitor increases temozolomide sensitivity in temozolomide-resistant glioblastoma cells. 2021 Mar 7
45 32813021 TGF-β1 modulates temozolomide resistance in glioblastoma via altered microRNA processing and elevated MGMT. 2021 Mar 25 4
46 32813186 Temozolomide treatment outcomes and immunotherapy efficacy in brain tumor. 2021 Jan 1
47 33037945 Optimal treatment strategy for adult patients with newly diagnosed glioblastoma: a systematic review and network meta-analysis. 2021 Aug 3
48 33040565 Narrative review of palliative hypofractionated radiotherapy for high grade glioma. 2021 Jan 4
49 33049091 Disentangling the therapeutic tactics in GBM: From bench to bedside and beyond. 2021 Jan 1
50 33085768 A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma. 2021 Mar 25 1