Title : Mannose inhibits proliferation and promotes apoptosis to enhance sensitivity of glioma cells to temozolomide through Wnt/β-catenin signaling pathway.

Pub. Date : 2022 Jul

PMID : 35490896






5 Functional Relationships(s)
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1 Mannose enhanced the sensitivity of glioma cells to TMZ, indicated by the further inhibited cell viability and colony formation and the aggravated cell apoptosis, which was reversed by overexpression of O6-methylguanine DNA methyltransferase (MGMT). Temozolomide O-6-methylguanine-DNA methyltransferase Homo sapiens
2 Mannose enhanced the sensitivity of glioma cells to TMZ, indicated by the further inhibited cell viability and colony formation and the aggravated cell apoptosis, which was reversed by overexpression of O6-methylguanine DNA methyltransferase (MGMT). Temozolomide O-6-methylguanine-DNA methyltransferase Homo sapiens
3 Furthermore, mannose and TMZ inhibited MGMT expression and Wnt/beta-catenin activation. Temozolomide O-6-methylguanine-DNA methyltransferase Homo sapiens
4 Moreover, activating Wnt/beta-catenin pathway blocked anti-proliferative effect induced by mannose and TMZ, which was further suppressed by overexpressed MGMT. Temozolomide O-6-methylguanine-DNA methyltransferase Homo sapiens
5 CONCLUSION: Mannose inhibited MGMT to enhance sensitivity of glioma cells to TMZ, with Wnt/beta-catenin pathway involvement. Temozolomide O-6-methylguanine-DNA methyltransferase Homo sapiens