Glutathione

solute carrier family 7 member 11 ; Homo sapiens







132 Article(s)
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51 32608563 Susceptibility to erastin-induced ferroptosis decreases during maturation in a human oligodendrocyte cell line. 2020 Sep 2
52 32677159 Role of the MUC1-C oncoprotein in the acquisition of cisplatin resistance by urothelial carcinoma. 2020 Oct 1
53 32755448 Role of metaplasia during gastric regeneration. 2020 Dec 1 2
54 32763516 Increased glutathione utilization augments tumor cell proliferation in Waldenstrom Macroglobulinemia. 2020 Sep 1
55 32782585 xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma. 2020 Sep 1
56 33024440 Transcript Isoforms of SLC7A11-AS1 Are Associated With Varicocele-Related Male Infertility. 2020 4
57 33112766 The SLC7A11: sperm mitochondrial function and non-canonical glutamate metabolism. 2020 Dec 1
58 33224345 Sulodexide increases mRNA expression of glutathione-related genes in human umbilical endothelial cells exposed to oxygen-glucose deprivation. 2020 1
59 33375092 Oxidative Stress, Glutathione Metabolism, and Liver Regeneration Pathways Are Activated in Hereditary Tyrosinemia Type 1 Mice upon Short-Term Nitisinone Discontinuation. 2020 Dec 22 1
60 30686770 Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers. 2019 Feb 11 1
61 30753819 Glutathione Metabolism: An Achilles' Heel of ARID1A-Deficient Tumors. 2019 Feb 11 1
62 30897333 Endothelial-Mesenchymal Transition Drives Expression of CD44 Variant and xCT in Pulmonary Hypertension. 2019 Sep 1
63 30907299 Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1. 2019 Apr 2
64 31000598 Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance. 2019 May 7 1
65 31019077 Cystine-glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity. 2019 May 7 2
66 31071489 Cystine/Glutamate Antiporter (xCT) Is Required for Chief Cell Plasticity After Gastric Injury. 2019 1
67 31175120 Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses. 2019 Aug 1 6
68 31419780 High SLC7A11 expression in normal skin of melanoma patients. 2019 Oct 4
69 31444923 Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma. 2019 Nov 3
70 31929797 mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance. 2019 1
71 32010620 Involvement of Glutathione Depletion in Selective Cytotoxicity of Oridonin to p53-Mutant Esophageal Squamous Carcinoma Cells. 2019 1
72 29385995 Variant isoforms of CD44 involves acquisition of chemoresistance to cisplatin and has potential as a novel indicator for identifying a cisplatin-resistant population in urothelial cancer. 2018 Jan 31 2
73 29702192 Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT. 2018 Aug 1 1
74 29764521 Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer. 2018 Apr 25 1
75 30190786 xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction. 2018 Aug 17 2
76 30405881 High expression level of CD44v8-10 in cancer stem-like cells is associated with poor prognosis in esophageal squamous cell carcinoma patients treated with chemoradiotherapy. 2018 Oct 9 2
77 27055559 Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205). 2017 Mar 2
78 27988976 Adaptive downregulation of pheomelanin-related Slc7a11 gene expression by environmentally induced oxidative stress. 2017 Feb 1
79 28073699 Activation of Nrf2 attenuates carbonyl stress induced by methylglyoxal in human neuroblastoma cells: Increase in GSH levels is a critical event for the detoxification mechanism. 2017 Feb 5 1
80 28153538 Photo-pollution stress in skin: Traces of pollutants (PAH and particulate matter) impair redox homeostasis in keratinocytes exposed to UVA1. 2017 May 1
81 28348409 Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation. 2017 Mar 28 2
82 28418922 Novel impact of the DNMT3A R882H mutation on GSH metabolism in a K562 cell model established by TALENs. 2017 May 2 5
83 28525376 Exploiting ROS and metabolic differences to kill cisplatin resistant lung cancer. 2017 Jul 25 1
84 28667792 Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer. 2017 Sep 1
85 28924227 Implication of the glutamate-cystine antiporter xCT in schizophrenia cases linked to impaired GSH synthesis. 2017 Sep 18 1
86 29057306 Inhibiting system xC- and glutathione biosynthesis - a potential Achilles' heel in mutant-p53 cancers. 2017 1
87 26698668 Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels. 2016 Mar 2
88 26820738 Inhibition of Prostaglandin Reductase 2, a Putative Oncogene Overexpressed in Human Pancreatic Adenocarcinoma, Induces Oxidative Stress-Mediated Cell Death Involving xCT and CTH Gene Expressions through 15-Keto-PGE2. 2016 4
89 26930718 Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells. 2016 Mar 15 4
90 27074570 Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema. 2016 Jun 14 1
91 27080807 xCT deficiency induces autophagy via endoplasmic reticulum stress activated p38-mitogen-activated protein kinase and mTOR in sut melanocytes. 2016 Jun-Jul 4
92 27279909 Redox Regulation of Stem-like Cells Though the CD44v-xCT Axis in Colorectal Cancer: Mechanisms and Therapeutic Implications. 2016 1
93 27347143 xCT expression modulates cisplatin resistance in Tca8113 tongue carcinoma cells. 2016 Jul 2
94 27421095 Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells. 2016 Jul 15 1
95 27612422 Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis. 2016 Nov 15 2
96 27658422 Increased Expression of System xc- in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance. 2016 Dec 3
97 25399695 Stress-induced inhibition of nonsense-mediated RNA decay regulates intracellular cystine transport and intracellular glutathione through regulation of the cystine/glutamate exchanger SLC7A11. 2015 Aug 6 4
98 25461272 Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry. 2015 Apr 30 2
99 25585997 Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function. 2015 Mar 2
100 25667445 Expression of xCT as a predictor of disease recurrence in patients with colorectal cancer. 2015 Feb 1