Thioridazine

cytochrome P450 family 2 subfamily D member 6 ; Homo sapiens







26 Article(s)
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1 26264841 Molecular dynamics and density functional studies on the metabolic selectivity of antipsychotic thioridazine by cytochrome P450 2D6: Connection with crystallographic and metabolic results. 2015 Sep 1 4
2 23476805 Comparative cytochrome p450 in vitro inhibition by atypical antipsychotic drugs. 2013 2
3 21976621 Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. 2012 Jan 1
4 28520378 Thioridazine Therapy and CYP2D6 Genotypes 2012 6
5 23226058 Role of cytochrome P450 genotype in the steps toward personalized drug therapy. 2011 1
6 19482014 Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s. 2009 Oct 7 1
7 19604081 Relevance of CYP2D6 -1584C>G polymorphism for thioridazine:mesoridazine plasma concentration ratio in psychiatric patients. 2009 Jul 11
8 19902987 Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II. 2009 1
9 17460606 Factors affecting drug concentrations and QT interval during thioridazine therapy. 2007 Nov 1
10 16272405 Characterization of human cytochrome p450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine. 2006 Mar 1
11 16472104 Prediction of drug-drug interactions for AUCoral of high clearance drug from in vitro data: utilization of a microtiter plate assay and a dispersion model. 2006 Feb 1
12 16805946 Role of CYP pharmacogenetics and drug-drug interactions in the efficacy and safety of atypical and other antipsychotic agents. 2006 Jul 1
13 15572279 Inhibition of rat liver CYP2D in vitro and after 1-day and long-term exposure to neuroleptics in vivo-possible involvement of different mechanisms. 2005 Jan 1
14 15260906 QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrations. 2004 Jun 1
15 12682803 Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype. 2003 May 9
16 12065442 Measurement of Michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach. 2002 Jul 1
17 12083975 Cytochrome p450 phenotyping/genotyping in patients receiving antipsychotics: useful aid to prescribing? 2002 1
18 12503836 QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients. 2002 Dec 2
19 11802093 Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes. 2001 Dec 4
20 10855463 Marked increase of venlafaxine enantiomer concentrations as a consequence of metabolic interactions: a case report. 2000 May 1
21 10942178 Use of the mesoridazine/thioridazine ratio as a marker for CYP2D6 enzyme activity. 2000 Aug 4
22 9143866 Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes. 1997 1
23 9352572 Effects of thioridazine, an inhibitor of CYP2D6, on the steady-state plasma concentrations of the enantiomers of mianserin and its active metabolite, desmethylmianserin, in depressed Japanese patients. 1997 Oct 3
24 9435993 Selective serotonin reuptake inhibitors and CNS drug interactions. A critical review of the evidence. 1997 Dec 1
25 8653995 Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin. 1996 Mar 1
26 8946674 Thioridazine interferences with imipramine metabolism and measurement. 1996 Dec 1