Pub. Date : 2009 Jul
PMID : 19604081
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Relevance of CYP2D6 -1584C>G polymorphism for thioridazine:mesoridazine plasma concentration ratio in psychiatric patients. | Thioridazine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 2 | However, the impact this SNP in the CYP2D6 promoter region has on plasma levels of patients taking CYP2D6 substrates, such as thioridazine, has not been studied. | Thioridazine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 3 | However, the impact this SNP in the CYP2D6 promoter region has on plasma levels of patients taking CYP2D6 substrates, such as thioridazine, has not been studied. | Thioridazine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 4 | Previously, we showed the validity of the mesoridazine:thioridazine ratio to assess CYP2D6 activity in clinical settings. | Thioridazine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 5 | Therefore, the aim of this study was to analyze the relationship between the presence of the CYP2D6 -1584C>G polymorphism and the plasma concentrations of thioridazine and its metabolites in a previously studied population of patients in order to evaluate the implications for CYP2D6 hydroxylation capacity. | Thioridazine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 6 | MATERIALS & METHODS: The CYP2D6 -1584C>G polymorphism was determined by using a PCR-RFLP method in 61 Caucasian psychiatric patients receiving thioridazine monotherapy. | Thioridazine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 7 | RESULTS: Among patients with two active CYP2D6 genes, there were significant differences in the thioridazine:mesoridazine plasma concentrations ratio (p < 0.05) among the three CYP2D6 -1584C>G genotype groups. | Thioridazine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 8 | RESULTS: Among patients with two active CYP2D6 genes, there were significant differences in the thioridazine:mesoridazine plasma concentrations ratio (p < 0.05) among the three CYP2D6 -1584C>G genotype groups. | Thioridazine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 9 | Moreover, in this group of patients the thioridazine:mesoridazine ratio was lower (p < 0.05) in carriers of CYP2D6 -1584G allele than in patients homozygous for CYP2D6 -1584C allele. | Thioridazine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 10 | Moreover, in this group of patients the thioridazine:mesoridazine ratio was lower (p < 0.05) in carriers of CYP2D6 -1584G allele than in patients homozygous for CYP2D6 -1584C allele. | Thioridazine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 11 | CONCLUSION: According to the present results the concentration ratio of thioridazine to mesoridazine was related to the CYP2D6 -1584C>G polymorphism. | Thioridazine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |