Title : Effects of FK506-binding protein 12 and FK506 on autophosphorylation of epidermal growth factor receptor.

Pub. Date : 1998 Apr 17

PMID : 9545268






2 Functional Relationships(s)
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1 Finally, FK506 and rapamycin, which are known to block the PPIase activity of FKBP12, induced a significant stimulation of EGF receptor autophosphorylation in intact A431 cells suggesting suppression of EGF receptor autophosphorylation by intracellular FKBP12 in vivo. Sirolimus FKBP prolyl isomerase 1A Homo sapiens
2 Finally, FK506 and rapamycin, which are known to block the PPIase activity of FKBP12, induced a significant stimulation of EGF receptor autophosphorylation in intact A431 cells suggesting suppression of EGF receptor autophosphorylation by intracellular FKBP12 in vivo. Sirolimus FKBP prolyl isomerase 1A Homo sapiens