Dicumarol

NAD(P)H quinone dehydrogenase 1 ; Rattus norvegicus







63 Article(s)
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1 32789798 β-Lapachone Induces Acute Oxidative Stress in Rat Primary Astrocyte Cultures that is Terminated by the NQO1-Inhibitor Dicoumarol. 2020 Oct 3
2 30443714 Dicoumarol Inhibits Multidrug Resistance Protein 1-Mediated Export Processes in Cultured Primary Rat Astrocytes. 2019 Feb 2
3 24598128 The influence of dicoumarol on the bioactivation of the carcinogen aristolochic acid I in rats. 2014 May 1
4 25638376 Dicoumarol inhibits rat NAD(P)H:quinone oxidoreductase in vitro and induces its expression in vivo. 2014 6
5 22115979 The level of menadione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion. 2012 Jan 15 2
6 23047025 The metabolism of 9-chloro-β-lapachone and its effects in isolated hepatocytes. The involvement of NAD(P)H:quinone oxidoreductase 1 (NQO1). 2012 Dec 5 1
7 20849151 Stable expression of short interfering RNA for DT-diaphorase induces neurotoxicity. 2010 Sep 20 1
8 19265190 Copper dopamine complex induces mitochondrial autophagy preceding caspase-independent apoptotic cell death. 2009 May 15 1
9 20387640 [Cytotoxicity of troglitazone, structural analogue of alpha-tocopherol is mediated by inhibition of NAD(P)H:quinone oxidoreductase]. 2009 Jul-Aug 1
10 18500786 Copper neurotoxicity in rat substantia nigra and striatum is dependent on DT-diaphorase inhibition. 2008 Jun 1
11 18661957 Differential enzymatic reductions governing the differential hypoxia-selective cytotoxicities of phenazine 5,10-dioxides. 2008 Sep 2
12 18703762 Coenzyme Q1 redox metabolism during passage through the rat pulmonary circulation and the effect of hyperoxia. 2008 Oct 1
13 17305492 Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation. 2007 Feb 3
14 17425337 Inhibition of VMAT-2 and DT-diaphorase induce cell death in a substantia nigra-derived cell line--an experimental cell model for dopamine toxicity studies. 2007 May 1
15 16499885 Coenzyme Q(1) depletes NAD(P)H and impairs recycling of ascorbate in astrocytes. 2006 Mar 17 1
16 15666291 Reductase-mediated metabolism of motexafin gadolinium (Xcytrin) in rat and human liver subcellular fractions and purified enzyme preparations. 2005 Mar 1
17 15715653 Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived from the substantia nigra. 2005 Mar 1
18 14729138 Enzymatic and nonenzymatic formation of reactive oxygen species from 6-anilino-5,8-quinolinequinone. 2004 Jan 5 1
19 14751451 Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicumarol, a DT-diaphorase inhibitor. 2004 Feb 2
20 15111234 Effects of the DT-diaphorase inhibitor dicumarol on striatal monoamine levels in L-DOPA and L-deprenyl pre-treated rats. 2004 1
21 15111240 Inhibition of DT-diaphorase potentiates the in vivo neurotoxic effect of intranigral injection of salsolinol in rats. 2004 1
22 12603827 Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo. 2003 Mar 1
23 12768337 Effect of dietary coenzyme Q and fatty acids on the antioxidant status of rat tissues. 2003 May 1
24 12815004 Induction of NAD(P)H quinone: oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats. 2003 Jun 1
25 12882764 Duroquinone reduction during passage through the pulmonary circulation. 2003 Nov 1
26 14695936 Hepatocyte metabolism of coenzyme Q1 (ubiquinone-5) to its sulfate conjugate decreases its antioxidant activity. 2003 2
27 14715443 MPP(+)-induced degeneration is potentiated by dicoumarol in cultures of the RCSN-3 dopaminergic cell line. Implications of neuromelanin in oxidative metabolism of dopamine neurotoxicity. 2003 1
28 11926994 Paraquat- and diquat-induced oxygen radical generation and lipid peroxidation in rat brain microsomes. 2002 Apr 1
29 12069105 Effect of dicumarol, a Nad(P)h: quinone acceptor oxidoreductase 1 (DT-diaphorase) inhibitor on ubiquinone redox cycling in cultured rat hepatocytes. 2002 Apr 5
30 20654563 Chromium (VI)-induced cytotoxicity to osteoblast-derived cells. 1999 Dec 1
31 9528687 Effects of butylated hydroxyanisole and dicoumarol on the toxicity of menadione to rats. 1998 Jan 30 1
32 9045901 Establishment by adriamycin exposure of multidrug-resistant rat ascites hepatoma AH130 cells showing low DT-diaphorase activity and high cross resistance to mitomycins. 1997 Jan 1
33 9266502 The two-electron quinone reductase DT-diaphorase generates and maintains the antioxidant (reduced) form of coenzyme Q in membranes. 1997 2
34 23889067 Determinants of MTT reduction in rat hepatocytes. 1997 2
35 8637908 The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems. 1996 Mar 19 1
36 8687482 Bioactivation of mitomycin antibiotics by aerobic and hypoxic Chinese hamster ovary cells overexpressing DT-diaphorase. 1996 Jun 28 2
37 8837752 Enzymatic and molecular aspects of the antioxidant effect of menadione in hepatic microsomes. 1996 Oct 1 1
38 7536024 Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase. 1995 Apr 1
39 7710944 Molecular mechanisms of tirapazamine (SR 4233, Win 59075)-induced hepatocyte toxicity under low oxygen concentrations. 1995 Apr 1
40 7966357 Cellular thiols as a determinant of responsiveness to menadione in cardiomyocytes. 1994 Jul 1
41 7982895 One- and two-electron reduction of quinones by rat liver subcellular fractions. 1994 Jun 2
42 8216372 Conversion of 4-nitroquinoline 1-oxide (4NQO) to 4-hydroxyaminoquinoline 1-oxide by a dicumarol-resistant hepatic 4NQO nitroreductase in rats and mice. 1993 Oct 5 1
43 8461317 Does lung NAD(P)H:quinone reductase (DT-diaphorase) play an antioxidant enzyme role in protection from hyperoxia? 1993 Mar 21 1
44 1375532 Modulation of trenimon-induced cytotoxicity by DT-diaphorase in isolated rat hepatocytes under aerobic versus hypoxic conditions. 1992 Jun 1 2
45 1377439 Metabolism by rat liver cytosol of illudin S, a toxic substance of Lampteromyces japonicus. II. Characterization of illudin S-metabolizing enzyme. 1992 Jan 1
46 1379126 Reduction of chromium(VI) to chromium(V) by rat liver cytosolic and microsomal fractions: is DT-diaphorase involved? 1992 Jul 2
47 1703398 Expression of mammalian DT-diaphorase in Escherichia coli: purification and characterization of the expressed protein. 1990 Dec 2
48 2105732 NAD(P)H: quinone oxidoreductase (DT-diaphorase) in chick embryo liver. Comparison to activity in rat and guinea pig liver and differences in co-induction with 7-ethoxyresorufin deethylase by 2,3,7,8-tetrachlorodibenzo-p-dioxin. 1990 Jan 15 1
49 2113029 Reduction of adrenochrome by rat liver and brain DT-diaphorase. 1990 1
50 2116241 Rat liver DT-diaphorase as a nitroso-reductase. 1990 Apr 1