Pub. Date : 2014
PMID : 25638376
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVES: Dicoumarol is known to act as an inhibitor of NAD(P)H: quinone oxidoreductase (NQO1). | Dicumarol | NAD(P)H quinone dehydrogenase 1 | Rattus norvegicus |
| 2 | However, it is still not known how dicoumarol influences the NQO1-mediated reductive bioactivation of AAI. | Dicumarol | NAD(P)H quinone dehydrogenase 1 | Rattus norvegicus |
| 3 | We however, demonstrated that dicoumarol acts as an inducer of NQO1 in kidney and lung of rats treated with this NQO1 inhibitor in vivo, both at protein and activity levels. | Dicumarol | NAD(P)H quinone dehydrogenase 1 | Rattus norvegicus |
| 4 | We however, demonstrated that dicoumarol acts as an inducer of NQO1 in kidney and lung of rats treated with this NQO1 inhibitor in vivo, both at protein and activity levels. | Dicumarol | NAD(P)H quinone dehydrogenase 1 | Rattus norvegicus |
| 5 | NQO1 mRNA levels were induced in liver only by dicoumarol. | Dicumarol | NAD(P)H quinone dehydrogenase 1 | Rattus norvegicus |
| 6 | CONCLUSION: Our results indicate a dual role of dicoumarol in NQO1-mediated genotoxicty of AAI. | Dicumarol | NAD(P)H quinone dehydrogenase 1 | Rattus norvegicus |