Diglycerides

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RAS guanyl releasing protein 1 ; Homo sapiens







44 Article(s)
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1 34529720 Biogenesis of P-TEFb in CD4+ T cells to reverse HIV latency is mediated by protein kinase C (PKC)-independent signaling pathways. 2021 Sep 2
2 28690878 The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells. 2017 Jun 1
3 28912101 Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3. 2017 Dec 1
4 26549032 RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines. 2016 Jul 14 4
5 27022025 Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity. 2016 May 20 2
6 27891502 Diacylglycerol Kinases in T Cell Tolerance and Effector Function. 2016 1
7 24794745 Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP. 2014 Jun 15 1
8 23589333 Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS. 2013 Jun 1
9 23847619 Regulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and Function. 2013 1
10 24280043 The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling. 2013 Nov 26 1
11 21138839 Decreased diacylglycerol metabolism enhances ERK activation and augments CD8+ T cell functional responses. 2011 Feb 18 4
12 21285350 Phosphoinositide 3-kinase regulates plasma membrane targeting of the Ras-specific exchange factor RasGRP1. 2011 Apr 8 3
13 21775687 Tight regulation of diacylglycerol-mediated signaling is critical for proper invariant NKT cell development. 2011 Sep 1 2
14 21966541 Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression. 2011 3
15 19100522 A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells. 2009 Jan 1
16 19628710 CalDAG-GEFI is at the nexus of calcium-dependent platelet activation. 2009 Sep 17 1
17 19896467 Functional links between diacylglycerol and phosphatidylinositol signaling systems in human leukocyte-derived cell lines. 2009 Dec 25 1
18 19933860 RasGRP1 is required for human NK cell function. 2009 Dec 15 1
19 18174897 Molecular regulation of T-cell anergy. 2008 Jan 2
20 18263588 Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta. 2008 Apr 18 1
21 17486117 The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. 2007 Jun 2
22 17523924 Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs. 2007 Sep 1 4
23 17567957 Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane. 2007 Aug 3
24 18077438 Phorbol ester stimulation of RasGRP1 regulates the sodium-chloride cotransporter by a PKC-independent pathway. 2007 Dec 11 2
25 17052215 Regulation of Ras in lymphocytes: get a GRP. 2006 Nov 2
26 15657177 Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells. 2005 May 1 3
27 15899849 A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. 2005 Jun 4
28 15923197 A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha. 2005 Jul 22 1
29 16042567 Compartmentalized signalling of Ras. 2005 Aug 1
30 14583629 Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation. 2004 Jan 9 8
31 14702343 Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1. 2004 Mar 19 1
32 15064353 Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes. 2004 Jun 1
33 12730099 Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3. 2003 Aug 15 5
34 11831896 Structural basis of RasGRP binding to high-affinity PKC ligands. 2002 Feb 14 2
35 11919165 Expression of a catalytically inactive form of diacylglycerol kinase alpha induces sustained signaling through RasGRP. 2002 Apr 1
36 12070163 Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta. 2002 Aug 23 2
37 12091553 ATP-inhibition of M current in frog sympathetic neurons involves phospholipase C but not Ins P(3), Ca(2+), PKC, or Ras. 2002 Jul 1
38 12414987 Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters. 2002 Dec 1 3
39 11257115 Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism. 2001 Mar 19 3
40 11503142 Guanine nucleotide exchange factors CalDAG-GEFI and CalDAG-GEFII are colocalized in striatal projection neurons. 2001 Sep 3 3
41 10779365 The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters. 2000 May 3
42 10807788 RasGRP links T-cell receptor signaling to Ras. 2000 May 15 2
43 9582122 RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs. 1998 May 15 4
44 9789079 A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. 1998 Oct 27 1