Title : RasGRP links T-cell receptor signaling to Ras.

Pub. Date : 2000 May 15

PMID : 10807788






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Here we show that RasGRP, a Ras activator that contains calcium-binding EF hands and a DAG-binding domain, is expressed in T cells. Diglycerides RAS guanyl releasing protein 1 Homo sapiens
2 Overexpression of RasGRP in T cells enhanced TCR-Ras-Erk signaling and augmented interleukin-2 secretion in response to calcium ionophore plus DAG analogues phorbol ester myristate or bryostatin-1. Diglycerides RAS guanyl releasing protein 1 Homo sapiens