quinone

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







8 Article(s)
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1 32184040 Synthesis and evaluation of nevirapine analogs to study the metabolic activation of nevirapine. 2020 Apr 1
2 25451576 Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity. 2014 Dec 5 1
3 22517972 Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme. 2012 Jul 1
4 20507089 Discovery tactics to mitigate toxicity risks due to reactive metabolite formation with 2-(2-hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3h)-one derivatives, potent calcium-sensing receptor antagonists and clinical candidate(s) for the treatment of osteoporosis. 2010 Jun 21 1
5 19358519 Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile. 2009 May 1
6 19364830 Metabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4. 2009 Jul 1
7 10534310 Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. 1999 Nov 4
8 9789061 Association of CYP3A4 genotype with treatment-related leukemia. 1998 Oct 27 1