8 Article(s)Download |
PMID | Title | Pub. Year | #Total Relationships |
1 | 32184040 | Synthesis and evaluation of nevirapine analogs to study the metabolic activation of nevirapine. | 2020 Apr | 1 |
2 | 25451576 | Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity. | 2014 Dec 5 | 1 |
3 | 22517972 | Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme. | 2012 Jul | 1 |
4 | 20507089 | Discovery tactics to mitigate toxicity risks due to reactive metabolite formation with 2-(2-hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3h)-one derivatives, potent calcium-sensing receptor antagonists and clinical candidate(s) for the treatment of osteoporosis. | 2010 Jun 21 | 1 |
5 | 19358519 | Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile. | 2009 May | 1 |
6 | 19364830 | Metabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4. | 2009 Jul | 1 |
7 | 10534310 | Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. | 1999 Nov | 4 |
8 | 9789061 | Association of CYP3A4 genotype with treatment-related leukemia. | 1998 Oct 27 | 1 |