Pub. Date : 1999 Nov
PMID : 10534310
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Of fourteen cDNA-expressed human P-450 enzymes examined, CYP1A1, CYP2C8, CYP2C19, and CYP3A4 were active in catalyzing formation of a quinone-type metabolite at a concentration of 10 microM troglitazone, whereas CYP3A4 had the highest catalytic activity at 100 microM substrate. | quinone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Of fourteen cDNA-expressed human P-450 enzymes examined, CYP1A1, CYP2C8, CYP2C19, and CYP3A4 were active in catalyzing formation of a quinone-type metabolite at a concentration of 10 microM troglitazone, whereas CYP3A4 had the highest catalytic activity at 100 microM substrate. | quinone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | The results suggest that in human liver both CYP2C8 and CYP3A4 have major roles in quinone-type metabolite formation and that the hepatic contents of these two P-450 forms determine which P-450 enzymes play major roles in individual humans. | quinone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | CYP3A4 may be expected to play a role in formation of quinone-type metabolite from troglitazone even at a low concentration in humans. | quinone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |