Title : Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme.

Pub. Date : 2012 Jul

PMID : 22517972






1 Functional Relationships(s)
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1 Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme. quinone cytochrome P450 family 3 subfamily A member 4 Homo sapiens