Title : Drug-Drug Interactions and Disease Status Are Associated With Irinotecan-Induced Hepatotoxicity: A Cross-Sectional Study in Shanghai.

Pub. Date : 2022 Apr 9

PMID : 35396702






1 Functional Relationships(s)
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1 The findings of this study suggest that irinotecan-induced hepatotoxicity is not directly associated with genetic variables but is mostly related to concomitant use of CYP3A inducers and platinum, as well as the presence of liver metastasis and CVD. Irinotecan cytochrome P450 family 3 subfamily A member 4 Homo sapiens