Quercetin

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







29 Article(s)
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1 34601070 Determination of effective concentrations of drug absorption enhancers using in vitro and ex vivo models. 2021 Dec 1 3
2 34646329 Exploring the Molecular Mechanism of Astragali Radix-Curcumae Rhizoma against Gastric Intraepithelial Neoplasia by Network Pharmacology and Molecular Docking. 2021 1
3 33260381 Screening of Human CYP1A2 and CYP3A4 Inhibitors from Seaweed In Silico and In Vitro. 2020 Nov 29 2
4 28232125 In vitro inhibition of human CYP2E1 and CYP3A by quercetin and myricetin in hepatic microsomes is not gender dependent. 2017 Apr 15 3
5 28462502 Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative. 2017 Aug 1
6 28867739 Inhibitory Effects of Juices Prepared from Individual Vegetables on CYP3A4 Activity in Recombinant CYP3A4 and LS180 Cells. 2017 1
7 26366751 Vitamin D Receptor-Mediated Upregulation of CYP3A4 and MDR1 by Quercetin in Caco-2 cells. 2016 Jan 3
8 25424246 Drug-drug Interaction between Losartan and Paclitaxel in Human Liver Microsomes with Different CYP2C8 Genotypes. 2015 Jun 1
9 25684704 Investigation of CYP3A4 and CYP2D6 Interactions of Withania somnifera and Centella asiatica in Human Liver Microsomes. 2015 May 1
10 25988261 The Influence of Single-Dose and Short-Term Administration of Quercetin on the Pharmacokinetics of Midazolam in Humans. 2015 Sep 2
11 26238175 3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease. 2015 Oct 2
12 25196644 Evaluation of inhibitory effects of caffeic acid and quercetin on human liver cytochrome p450 activities. 2014 Dec 1
13 23434495 Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. 2013 Apr 15 1
14 21680781 Effect of quercetin on CYP3A activity in Chinese healthy participants. 2012 Jun 3
15 22421793 Modeling chemical interaction profiles: II. Molecular docking, spectral data-activity relationship, and structure-activity relationship models for potent and weak inhibitors of cytochrome P450 CYP3A4 isozyme. 2012 Mar 15 1
16 21466223 Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4. 2011 May 11 3
17 21832258 Luciferin IPA-based higher throughput human hepatocyte screening assays for CYP3A4 inhibition and induction. 2011 Sep 1
18 19766177 CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells. 2009 Dec 15 2
19 18559486 Blood monocyte-derived neohepatocytes as in vitro test system for drug metabolism. 2008 Sep 1
20 18653741 CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid chromatography-tandem mass spectrometry and liquid chromatography/mass spectrometry-nuclear magnetic resonance. 2008 Oct 1
21 17581220 Induction of cyp3a in primary cultures of human hepatocytes by ginkgolides a and B. 2007 Jul 1
22 16442130 MDR- and CYP3A4-mediated drug-herbal interactions. 2006 Mar 27 1
23 15133536 The inhibitory effects of herbal components on CYP2C9 and CYP3A4 catalytic activities in human liver microsomes. 2004 May-Jun 1
24 15266218 In vitro interaction of the HIV protease inhibitor ritonavir with herbal constituents: changes in P-gp and CYP3A4 activity. 2004 Jul-Aug 2
25 15365656 Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. 2004 Oct 1
26 12695340 Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products. 2003 May 2
27 12936704 Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes. 2003 Aug 1
28 10534310 Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. 1999 Nov 1
29 7634387 Quercetin not only inhibits P-glycoprotein efflux activity but also inhibits CYP3A isozymes. 1995 1