Pub. Date : 2015 Sep
PMID : 25988261
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To investigate the effect of acute and short-term intake of high-dose quercetin on CYP3A-mediated metabolism, 10 healthy volunteers received 7.5 mg oral midazolam without, with a single dose of 1500 mg quercetin and after 1-week supplementation with 1500 mg quercetin daily. | Quercetin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | We conclude that a single dose of quercetin would not provoke any toxic adverse events when coadministered with midazolam, whereas repeated quercetin intake can reduce systemic exposure to the orally given drug by increasing its CYP3A-catalyzed metabolism. | Quercetin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |