Title : Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products.

Pub. Date : 2003 May

PMID : 12695340






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Only quercetin produced accumulation of CYP3A4 mRNA (230 +/- 73% of control). Quercetin cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 When examined in a reporter gene assay, this flavonoid exhibited negligible increases in luciferase activity suggesting that quercetin induced CYP3A4 by mechanisms that may not involve PXR. Quercetin cytochrome P450 family 3 subfamily A member 4 Homo sapiens