Guanosine Triphosphate

Rac family small GTPase 1 ; Homo sapiens







344 Article(s)
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1 34882832 FGD5 regulates endothelial cell PI3 kinase-β to promote neo-angiogenesis. 2022 Jan 1
2 34983065 Inactivating Celsr2 promotes motor axon fasciculation and regeneration in mouse and human. 2022 Apr 18 1
3 35215978 Vav Proteins in Development of the Brain: A Potential Relationship to the Pathogenesis of Congenital Zika Syndrome? 2022 Feb 14 1
4 35319996 Local temporal Rac1-GTP nadirs and peaks restrict cell protrusions and retractions. 2022 Mar 25 4
5 35583642 Targeting Cancer by Using Nanoparticles to Modulate RHO GTPase Signaling. 2022 1
6 33217330 Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1. 2021 Mar 4 2
7 33515600 Oncogenic mutations on Rac1 affect global intrinsic dynamics underlying GTP and PAK1 binding. 2021 Mar 2 3
8 33660564 Biallelic ELMO3 mutations and loss of function for DOCK-mediated RAC1 activation result in intellectual disability. 2021 Mar 4 1
9 33683574 B3GNT3 acts as a carcinogenic factor in endometrial cancer via facilitating cell growth, invasion and migration through regulating RhoA/RAC1 pathway-associated markers. 2021 May 1
10 33848152 Mechanistic Differences of Activation of Rac1P29S and Rac1A159V. 2021 Apr 22 3
11 33871166 Enterovirus-A71 exploits peripherin and Rac1 to invade the central nervous system. 2021 Jun 4 1
12 33977469 Regulation of the Small GTPase Ras and Its Relevance to Human Disease. 2021 1
13 34252134 The interplay of Rac1 activity, ubiquitination and GDI binding and its consequences for endothelial cell spreading. 2021 1
14 34287745 22-O-(N-Boc-L-glycine) ester of renieramycin M inhibits migratory activity and suppresses epithelial-mesenchymal transition in human lung cancer cells. 2021 Sep 1
15 34321603 Fermitin family member 2 promotes melanoma progression by enhancing the binding of p-α-Pix to Rac1 to activate the MAPK pathway. 2021 Sep 2
16 34607932 Efficacy of Rac and Cdc42 Inhibitor MBQ-167 in Triple-negative Breast Cancer. 2021 Dec 1
17 34667203 Regulation of local GTP availability controls RAC1 activity and cell invasion. 2021 Oct 19 14
18 34741006 Author Correction: Regulation of local GTP availability controls RAC1 activity and cell invasion. 2021 Nov 5 1
19 31996022 Statins Disrupt Macrophage Rac1 Regulation Leading to Increased Atherosclerotic Plaque Calcification. 2020 Mar 1
20 32126869 Association between thiopurine exposure and depression in patients with inflammatory bowel disease and rheumatoid arthritis. 2020 Oct 2
21 32178475 Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis. 2020 Mar 12 1
22 32238860 PLCE1 regulates the migration, proliferation, and differentiation of podocytes. 2020 Apr 1
23 32314182 Rac1 activation in human breast carcinoma as a prognostic factor associated with therapeutic resistance. 2020 Sep 4
24 32545340 Active RAC1 Promotes Tumorigenic Phenotypes and Therapy Resistance in Solid Tumors. 2020 Jun 11 1
25 32817335 Evaluation of active Rac1 levels in cancer cells: A case of misleading conclusions from immunofluorescence analysis. 2020 Oct 2 4
26 30621237 RAC1B: A Rho GTPase with Versatile Functions in Malignant Transformation and Tumor Progression. 2019 Jan 4 2
27 30891502 Conformational landscape alternations promote oncogenic activities of Ras-related C3 botulinum toxin substrate 1 as revealed by NMR. 2019 Mar 5
28 30959099 Tumor-secreted GRP78 facilitates the migration of macrophages into tumors by promoting cytoskeleton remodeling. 2019 Aug 3
29 30981505 Structural and functional characterization of fast-cycling RhoF GTPase. 2019 May 28 1
30 31019460 NEDD9 Facilitates Hypoxia-Induced Gastric Cancer Cell Migration via MICAL1 Related Rac1 Activation. 2019 1
31 31095421 Rac-GTPase promotes fibrotic TGF-β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways. 2019 Sep 1
32 31321300 HACE1 deficiency leads to structural and functional neurodevelopmental defects. 2019 Jun 2
33 31330900 The Intrinsic GDP/GTP Exchange Activities of Cdc42 and Rac1 Are Critical Determinants for Their Specific Effects on Mobilization of the Actin Filament System. 2019 Jul 21 1
34 31396321 Platelet-rich plasma in combination with adipose-derived stem cells promotes skin wound healing through activating Rho GTPase-mediated signaling pathway. 2019 1
35 31457101 Decreased conformational stability in the oncogenic N92I mutant of Ras-related C3 botulinum toxin substrate 1. 2019 Aug 4
36 31609760 The signaling axis of Rac1-TFEB regulates autophagy and tumorigenesis. 2019 Nov 1
37 31759406 KIF18B as a regulator in microtubule movement accelerates tumor progression and triggers poor outcome in lung adenocarcinoma. 2019 Dec 1
38 33405555 Integrin-Induced Signal Event Contributes to Self-Assembled Monolayers on Au-Nanoparticle-Regulated Cancer Cell Migration and Invasion. 2019 Apr 8 1
39 27588611 The P-Rex1/Rac signaling pathway as a point of convergence for HER/ErbB receptor and GPCR responses. 2018 Jul 4 1
40 29196061 Direct regulation of p190RhoGEF by activated Rho and Rac GTPases. 2018 Apr 1
41 29321004 RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation. 2018 Jan 10 1
42 29355935 Electrical pulse stimulation induces GLUT4 translocation in a Rac-Akt-dependent manner in C2C12 myotubes. 2018 Feb 1
43 29358323 Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2. 2018 Mar 9 1
44 29432733 DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation. 2018 Feb 26 2
45 29534468 ARHGAP15 in Human Breast Carcinoma: A Potent Tumor Suppressor Regulated by Androgens. 2018 Mar 10 2
46 29670612 N-Formyl Peptide Receptors Induce Radical Oxygen Production in Fibroblasts Derived From Systemic Sclerosis by Interacting With a Cleaved Form of Urokinase Receptor. 2018 1
47 29717062 VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP β2-chimaerin. 2018 May 1 2
48 29884911 RAC1-GTP promotes epithelial-mesenchymal transition and invasion of colorectal cancer by activation of STAT3. 2018 Aug 1
49 29920300 6-Thioguanine inhibits rotavirus replication through suppression of Rac1 GDP/GTP cycling. 2018 Aug 1
50 29967243 Rac1 Nanoscale Organization on the Plasma Membrane Is Driven by Lipid Binding Specificity Encoded in the Membrane Anchor. 2018 Sep 15 3