Pub. Date : 2021 Mar 2
PMID : 33515600
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oncogenic mutations on Rac1 affect global intrinsic dynamics underlying GTP and PAK1 binding. | Guanosine Triphosphate | Rac family small GTPase 1 | Homo sapiens |
| 2 | On the other hand, Rac1"s intrinsic dynamics reveal more flexible GTP and PAK1-binding residues on Switch I and II with Q61L, Y72C, oncogenic P29S and Q61R and negative T17N mutations. | Guanosine Triphosphate | Rac family small GTPase 1 | Homo sapiens |
| 3 | Overall, these findings suggest that the active mutations affect intrinsic functional dynamic events and alter the mechanics underlying the binding of Rac1 to GTP and upstream/downstream partners including PAK1. | Guanosine Triphosphate | Rac family small GTPase 1 | Homo sapiens |