Tyrosine

signal transducer and activator of transcription 5A ; Homo sapiens







255 Article(s)
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51 23036105 Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes. 2012 Oct 4 1
52 21220747 High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia. 2011 Mar 24 2
53 21233313 The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. 2011 Mar 24 1
54 21368206 Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses. 2011 Mar 15 1
55 21576635 Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure. 2011 Jun 20 1
56 21617857 EGF stimulates cyclooxygenase-2 expression through the STAT5 signaling pathway in human lung adenocarcinoma A549 cells. 2011 Aug 2
57 21622220 Serine phosphorylation of the Stat5a C-terminus is a driving force for transformation. 2011 Jun 1 1
58 21716071 HIV infection perturbs interleukin-7 signaling at the step of STAT5 nuclear relocalization. 2011 Sep 24 1
59 19923221 Protein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation. 2010 Feb 5 2
60 20127673 Thymic stromal lymphopoietin induces early human B-cell proliferation and differentiation. 2010 Apr 1
61 20372794 Enforced SOCS1 and SOCS3 expression attenuates Lck-mediated cellular transformation. 2010 May 2
62 20495002 Ectodomain shedding of interleukin-2 receptor beta and generation of an intracellular functional fragment. 2010 Jul 16 1
63 20870009 Rhizoctonia bataticola lectin (RBL) induces mitogenesis and cytokine production in human PBMC via p38 MAPK and STAT-5 signaling pathways. 2010 Dec 1
64 20952588 PTP1B suppresses prolactin activation of Stat5 in breast cancer cells. 2010 Dec 2
65 18996136 Novel actions of estrogen to promote proliferation: integration of cytoplasmic and nuclear pathways. 2009 Jul 1
66 19100521 Tel/PDGFRbeta induces stem cell differentiation via the Ras/ERK and STAT5 signaling pathways. 2009 Jan 1
67 19273609 Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation. 2009 May 1
68 19347282 Molecular characterization of STAT signaling in inflammation and tumorigenesis. 2009 1
69 20196786 Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling. 2009 Sep 1
70 17846080 Constitutive nuclear import of latent and activated STAT5a by its coiled coil domain. 2008 Feb 4
71 17890450 A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling. 2008 Jan 1 2
72 18063684 Activation of SRC kinase and phosphorylation of signal transducer and activator of transcription-5 are required for decidual transformation of human endometrial stromal cells. 2008 Mar 1
73 18197699 Modulation of STAT5 interaction with LMW-PTP during early megakaryocyte differentiation. 2008 Feb 12 2
74 18550772 Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells. 2008 Aug 3
75 18628457 Transformation by oncogenic mutants and ligand-dependent activation of FLT3 wild-type requires the tyrosine residues 589 and 591. 2008 Jul 15 2
76 19136996 Leptin receptor signaling and the regulation of mammalian physiology. 2008 Dec 1
77 17161871 Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cell. 2007 Jan 15 1
78 17503465 Tyrosine-phosphorylated STAT5 accumulates on podosomes in Hck-transformed fibroblasts and chronic myeloid leukemia cells. 2007 Oct 3
79 17505063 The HER4 cytoplasmic domain, but not its C terminus, inhibits mammary cell proliferation. 2007 Aug 4
80 17609438 Regulation of suppressor of cytokine signaling 3 (SOC3) by growth hormone in pro-B cells. 2007 Oct 1
81 17764157 Proapoptotic function of the nuclear Crk II adaptor protein. 2007 Sep 25 1
82 17785772 Cutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase. 2007 Sep 15 6
83 16407271 Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways. 2006 Mar 3 1
84 16527988 Novel role for STAT-5B in the regulation of Hsp27-FGF-2 axis facilitating thrombin-induced vascular smooth muscle cell growth and motility. 2006 Apr 14 1
85 16529541 Signal transducers and activators of transcription (STATs): Novel targets of chemopreventive and chemotherapeutic drugs. 2006 Mar 1
86 16532027 Constitutive STAT5 activation specifically cooperates with the loss of p53 function in B-cell lymphomagenesis. 2006 Aug 3 2
87 16568084 The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells. 2006 Aug 17 1
88 16568834 [Activation of transcriptional factors stat5 and stat3 during human T-lymphocyte proliferation induced by different mitogenic stimuli]. 2006 1
89 16569768 Proteasome-dependent down-regulation of activated Stat5A in the nucleus. 2006 Jul 15 2
90 16650892 Src transduces signaling via growth hormone (GH)-activated GH receptor (GHR) tyrosine-phosphorylating GHR and STAT5 in human leukemia cells. 2006 Nov 3
91 16757551 GH receptor signaling in skeletal muscle and adipose tissue in human subjects following exposure to an intravenous GH bolus. 2006 Nov 1
92 16765629 A role for the cytoskeleton in STAT5 activation in MCF7 human breast cancer cells stimulated with EGF. 2006 2
93 16950496 Spatio-temporal kinetics of growth hormone receptor signaling in single cells using FRET microscopy. 2006 Aug 1
94 15345593 Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML). 2005 Jan 1 2
95 15536163 A novel C-terminal growth hormone receptor (GHR) mutation results in impaired GHR-STAT5 but normal STAT-3 signaling. 2005 Jan 1
96 15671147 Stem cell factor synergistically enhances thrombopoietin-induced STAT5 signaling in megakaryocyte progenitors through JAK2 and Src kinase. 2005 Feb 3
97 15702476 Activation of STAT5-dependent transcription by the neurotrophin receptor Trk. 2005 May 1
98 15711548 STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression. 2005 Mar 1
99 15727811 Coactivators in gene regulation by STAT5. 2005 1
100 15863494 ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events. 2005 Jun 24 5