Tyrosine

signal transducer and activator of transcription 5A ; Homo sapiens







255 Article(s)
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1 34665271 Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3. 2022 Jan 1
2 33075386 Phosphorylated proteome analysis of a novel germline ABL1 mutation causing an autosomal dominant syndrome with ventricular septal defect. 2021 Mar 1 1
3 34188118 Serine residues 726 and 780 have nonredundant roles regulating STAT5a activity in luminal breast cancer. 2021 Jun 29 2
4 31963765 Pharmacological Inhibition of Oncogenic STAT3 and STAT5 Signaling in Hematopoietic Cancers. 2020 Jan 18 1
5 29939941 Novel IL2RG Mutation Causes Leaky TLOWB+NK+ SCID With Nodular Regenerative Hyperplasia and Normal IL-15 STAT5 Phosphorylation. 2019 May 1
6 30818760 Cell Metabolism Control Through O-GlcNAcylation of STAT5: A Full or Empty Fuel Tank Makes a Big Difference for Cancer Cell Growth and Survival. 2019 Feb 27 3
7 30835430 The STAT5b Linker Domain Mediates the Selectivity of Catechol Bisphosphates for STAT5b over STAT5a. 2019 Apr 19 2
8 31085588 CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells. 2019 Jul 1 1
9 31172340 Fractalkine Induces Hepcidin Expression of BV-2 Microglia and Causes Iron Accumulation in SH-SY5Y Cells. 2019 Oct 1
10 31861239 A Novel Inhibitor of STAT5 Signaling Overcomes Chemotherapy Resistance in Myeloid Leukemia Cells. 2019 Dec 17 1
11 31861720 Activation of STAT3 and STAT5 Signaling in Epithelial Ovarian Cancer Progression: Mechanism and Therapeutic Opportunity. 2019 Dec 19 1
12 32041920 The Role of STAT5 in Tyrosine Kinase Inhibitor (IMATINIB) Resistance in CML Patients. 2019 Oct 2
13 29200404 STAT5BN642H is a driver mutation for T cell neoplasia. 2018 Jan 2 1
14 29249817 Drug-induced inhibition of phosphorylation of STAT5 overrides drug resistance in neoplastic mast cells. 2018 Apr 1
15 29857127 Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model. 2018 Sep 1 1
16 30157040 RITA induces apoptosis in p53-null K562 leukemia cells by inhibiting STAT5, Akt, and NF-κB signaling pathways. 2018 Oct 1
17 28074064 O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies. 2017 Oct 6
18 28287479 STAT5-Interacting Proteins: A Synopsis of Proteins that Regulate STAT5 Activity. 2017 Mar 11 4
19 28400581 Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b. 2017 Apr 11 1
20 28468777 The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34+ Stem/Progenitor Cells. 2017 Aug 1
21 28629523 Significance of Erythropoietin Receptor Antagonist EMP9 in Cancers. 2017 1
22 28982698 Pyruvate dehydrogenase complex (PDC) subunits moonlight as interaction partners of phosphorylated STAT5 in adipocytes and adipose tissue. 2017 Dec 1 2
23 26059750 The growth hormone receptor. 2016 Jun 1
24 26702099 Cytokine-induced megakaryocytic differentiation is regulated by genome-wide loss of a uSTAT transcriptional program. 2016 Mar 15 1
25 26911335 Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTPε and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma. 2016 Feb 25 1
26 27076853 CSF2 Overexpression Is Associated with STAT5 Phosphorylation and Poor Prognosis in Patients with Urothelial Carcinoma. 2016 1
27 27312066 Validation of tumor protein marker quantification by two independent automated immunofluorescence image analysis platforms. 2016 Oct 1
28 27752093 Intramolecular hydrophobic interactions are critical mediators of STAT5 dimerization. 2016 Oct 18 1
29 27936140 Time-Dependent Regulation of IL-2R α-Chain (CD25) Expression by TCR Signal Strength and IL-2-Induced STAT5 Signaling in Activated Human Blood T Lymphocytes. 2016 1
30 30695496 [THE BRAIN LEPTIN SIGNALING SYSTEM AND ITS FUNCTIONAL STATE IN METABOLIC SYNDROME AND TYPE 2 DIABETES MELLITIS]. 2016 Mar 1
31 25821217 A novel IL-25 signaling pathway through STAT5. 2015 May 1 1
32 25885255 Src family kinases interfere with dimerization of STAT5A through a phosphotyrosine-SH2 domain interaction. 2015 Feb 15 3
33 25987027 Angelica sinensis polysaccharide induces erythroid differentiation of human chronic myelogenous leukemia k562 cells. 2015 1
34 24263804 PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. 2014 Mar 1
35 24821382 Activation of STAT5 contributes to proliferation in U87 human glioblastoma multiforme cells. 2014 Jul 3
36 24836440 BCR-ABL affects STAT5A and STAT5B differentially. 2014 1
37 24952131 Suppression of prolactin signaling by pyrrolidine dithiocarbamate is alleviated by N-acetylcysteine in mammary epithelial cells. 2014 Sep 5 1
38 25153147 Ancient origins and evolutionary conservation of intracellular and neural signaling pathways engaged by the leptin receptor. 2014 Nov 1
39 21868263 JAK3 in clear cell renal cell carcinoma: mutational screening and clinical implications. 2013 Aug 1
40 23332799 Role of arachidonic acid metabolism in Stat5 activation induced by oleic acid in MDA-MB-231 breast cancer cells. 2013 Mar 1
41 23596048 Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia. 2013 May 30 1
42 23600834 Paediatric Crohn disease patients with stricturing behaviour exhibit ileal granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody production and reduced neutrophil bacterial killing and GM-CSF bioactivity. 2013 Jun 2
43 23980167 SIRT1 regulates adaptive response of the growth hormone--insulin-like growth factor-I axis under fasting conditions in liver. 2013 Sep 10 2
44 24040307 Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplication. 2013 1
45 24751667 Incorporation of ortho- and meta-tyrosine into cellular proteins leads to erythropoietin-resistance in an erythroid cell line. 2013 1
46 25509109 [The STAT5 signaling in the expression of alpha-subunit of interleukin-2 receptor in human blood lymphocytes]. 2013 4
47 21678418 The RhoA-Rok-myosin II pathway is involved in extracellular matrix-mediated regulation of prolactin signaling in mammary epithelial cells. 2012 Apr 1
48 22297723 Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease. 2012 Jul 1
49 22411868 SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML. 2012 Apr 26 1
50 22528658 Structural basis of interleukin-5 dimer recognition by its α receptor. 2012 Jun 1