| 1 |
33672296 | A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-α Release in Human Lymphoblasts. | 2021 Feb 23 |
2 |
| 2 |
32167135 | Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies. | 2020 Apr 17 |
1 |
| 3 |
32180220 | GTP-binding inhibitors increase LRRK2-linked ubiquitination and Lewy body-like inclusions. | 2020 Oct |
7 |
| 4 |
32268075 | X Caps the Phosphate for Phospho-Rab GTPase Recognition in Ciliogenesis and Parkinson's Disease. | 2020 Apr 7 |
1 |
| 5 |
32631998 | Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity. | 2020 Jul 21 |
2 |
| 6 |
32853409 | LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes. | 2020 Oct 15 |
1 |
| 7 |
33122997 | Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery. | 2020 |
1 |
| 8 |
30592623 | The Parkinson's disease-associated mutation N1437H impairs conformational dynamics in the G domain of LRRK2. | 2019 Apr |
1 |
| 9 |
30796162 | Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics. | 2019 Apr 12 |
1 |
| 10 |
31624137 | Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases. | 2019 Dec 2 |
2 |
| 11 |
29177506 | LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network. | 2018 Jan 15 |
8 |
| 12 |
29212815 | Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. | 2018 Jan 4 |
2 |
| 13 |
29903014 | LRRK 2 gene mutations in the pathophysiology of the ROCO domain and therapeutic targets for Parkinson's disease: a review. | 2018 Jun 14 |
3 |
| 14 |
30067506 | Biochemical and kinetic properties of the complex Roco G-protein cycle. | 2018 Nov 27 |
2 |
| 15 |
32714591 | Physiological and pathological functions of LRRK2: implications from substrate proteins. | 2018 Dec |
2 |
| 16 |
27939437 | The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro. | 2017 Mar |
4 |
| 17 |
28202667 | LRRK2: from kinase to GTPase to microtubules and back. | 2017 Feb 8 |
5 |
| 18 |
29044096 | A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover. | 2017 Oct 18 |
1 |
| 19 |
27013965 | Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity. | 2016 |
1 |
| 20 |
27913671 | L'RRK de Triomphe: a solution for LRRK2 GTPase activity? | 2016 Dec 15 |
2 |
| 21 |
28119604 | 68 and FX2149 Attenuate Mutant LRRK2-R1441C-Induced Neural Transport Impairment. | 2016 |
6 |
| 22 |
24788225 | The role of LRRK2 in the regulation of monocyte adhesion to endothelial cells. | 2015 Jan |
2 |
| 23 |
24904275 | LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex. | 2014 |
1 |
| 24 |
23241358 | GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2. | 2013 Mar 15 |
4 |
| 25 |
22363216 | GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1. | 2012 |
3 |
| 26 |
22988866 | The GTPase function of LRRK2. | 2012 Oct |
2 |
| 27 |
21676337 | Role of LRRK2 kinase dysfunction in Parkinson disease. | 2011 Jun 13 |
1 |
| 28 |
21858031 | LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding. | 2011 |
9 |
| 29 |
22077787 | Leucine-rich repeat kinase 2 (LRRK2) cellular biology: a review of recent advances in identifying physiological substrates and cellular functions. | 2011 Dec |
1 |
| 30 |
20382224 | LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease. | 2010 Oct |
1 |
| 31 |
20386743 | GTPase activity plays a key role in the pathobiology of LRRK2. | 2010 Apr 8 |
1 |
| 32 |
20515039 | Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation. | 2010 Jul 6 |
1 |
| 33 |
20669305 | Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease. | 2010 Oct 15 |
1 |
| 34 |
21048939 | ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. | 2010 Oct 29 |
1 |
| 35 |
21060682 | Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif. | 2010 Oct 27 |
1 |
| 36 |
19712061 | Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment. | 2009 Nov |
1 |
| 37 |
20001906 | The small GTPase activity of the ROC domain from LRRK2, a Parkinson's disease related protein. | 2009 |
1 |
| 38 |
20041156 | The WD40 domain is required for LRRK2 neurotoxicity. | 2009 Dec 24 |
1 |
| 39 |
17200152 | Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. | 2007 Jan 15 |
1 |
| 40 |
17260967 | GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease. | 2007 Feb 6 |
2 |
| 41 |
17442267 | The R1441C mutation of LRRK2 disrupts GTP hydrolysis. | 2007 Jun 8 |
2 |
| 42 |
17706965 | The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity. | 2007 Oct 1 |
4 |
| 43 |
16980962 | Kinase activity of mutant LRRK2 mediates neuronal toxicity. | 2006 Oct |
1 |