Dexmedetomidine

adrenergic receptor, alpha 2a ; Mus musculus







19 Article(s)
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Pub. Year
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1 33039659 Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central α2A adrenoceptor. 2021 Jan 2
2 34884552 Dexmedetomidine Promotes Lipopolysaccharide-Induced Differentiation of Cardiac Fibroblasts and Collagen I/III Synthesis through α2A Adrenoreceptor-Mediated Activation of the PKC-p38-Smad2/3 Signaling Pathway in Mice. 2021 Nov 25 1
3 29729264 Dexmedetomidine attenuates renal fibrosis via α2-adrenergic receptor-dependent inhibition of cellular senescence after renal ischemia/reperfusion. 2018 Aug 15 2
4 25655994 Alpha-2 agonist attenuates ischemic injury in spinal cord neurons. 2015 May 1 1
5 26086861 Contribution of α2A-adrenoceptor subtype to effect of dexmedetomidine and xylazine on spinal synaptic transmission of mice. 2015 Aug 15 3
6 23850057 Interruption of spinal cord microglial signaling by alpha-2 agonist dexmedetomidine in a murine model of delayed paraplegia. 2014 Apr 1
7 24035379 Dexmedetomidine, an α-2a adrenergic agonist, promotes ischemic tolerance in a murine model of spinal cord ischemia-reperfusion. 2014 Jan 4
8 22832266 Attenuation of spinal cord ischemia-reperfusion injury by specific α-2a receptor activation with dexmedetomidine. 2012 Nov 7
9 21054403 Systemic daily morphine enhances the analgesic effect of intrathecal dexmedetomidine via up-regulation of alpha 2 adrenergic receptor subtypes A, B and C in dorsal root ganglion and dorsal horn. 2010 Dec 1
10 16428542 The effects of dexmedetomidine on perinatal excitotoxic brain injury are mediated by the alpha2A-adrenoceptor subtype. 2006 Feb 1
11 15039766 Alpha2A-adrenoceptors are important modulators of the effects of D-amphetamine on startle reactivity and brain monoamines. 2004 Jul 3
12 15464093 Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype. 2004 Oct 11 5
13 12726820 Alpha2-adrenergic drug effects on brain monoamines, locomotion, and body temperature are largely abolished in mice lacking the alpha2A-adrenoceptor subtype. 2003 Jun 1
14 12081658 In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse prefrontal cortex. 2002 Jun 1
15 11309255 Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine. 2001 Apr 4
16 10930558 Receptor subtype and dose dependence of dexmedetomidine-induced accumulation of [14C]glutamine in astrocytes suggests glial involvement in its hypnotic-sedative and anesthetic-sparing effects. 2000 Aug 11 1
17 9605427 Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding. 1998 Apr 1 1
18 9692731 D-amphetamine and L-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the alpha2C-adrenergic receptor subtype. 1998 Oct 1
19 9421280 Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice. 1997 Dec 4